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10.1007/s00018-013-1402-5 http://scihub22266oqcxt.onion/10.1007/s00018-013-1402-5 23793543!ä!23793543 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Mol+Life+Sci 2013 ; 70 (22): 4399-410 Nephropedia Template TP {{tp|p=23793543|t=2013. Absence of a robust innate immune response in rat neurons facilitates persistent infection of Borna disease virus in neuronal tissue |pdf=|usr=}}{{23793543}} gab.com Text Absence of a robust innate immune response in rat neurons facilitates persistent infection of Borna disease virus in neuronal tissue JO: Cell Mol Life Sci http://www.kidney.de/pget.php?&tw=1&pmid=23793543 #FOAvip Borna disease virus (BDV) persistently infects neurons of the central nervous system of various hosts, including rats. Since type I IFN-mediated antiviral response efficiently blocks BDV replication in primary rat embryo fibroblasts, it has been speculated that BDV is not effectively sensed by the host innate immune system in the nervous system. To test this assumption, organotypical rat hippocampal slice cultures were infected with BDV for up to 4 weeks. This resulted in the secretion of IFN and the up-regulation of IFN-stimulated genes. Using the rat Mx protein as a specific marker for IFN-induced gene expression, astrocytes and microglial cells were found to be Mx positive, whereas neurons, the major cell type in which BDV is replicating, lacked detectable levels of Mx protein. In uninfected cultures, neurons also remained Mx negative even after treatment with high concentrations of IFN-alpha. This non-responsiveness correlated with a lack of detectable nuclear translocation of both pSTAT1 and pSTAT2 in these cells. Consistently, neuronal dissemination of BDV was not prevented by treatment with IFN-alpha. These data suggest that the poor innate immune response in rat neurons renders this cell type highly susceptible to BDV infection even in the presence of exogenous IFN-alpha. Intriguingly, in contrast to rat neurons, IFN-alpha treatment of mouse neurons resulted in the up-regulation of Mx proteins and block of BDV replication, indicating species-specific differences in the type I IFN response of neurons between mice and rats. Twit Text FOAVip Absence of a robust innate immune response in rat neurons facilitates persistent infection of Borna disease virus in neuronal tissue ????Cell Mol Life Sci http://www.kidney.de/pget.php?&tw=1&pmid=23793543 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=23793543 #FOAvip English Wikipedia <ref>{{Cite pmid|23793543}}</ref> Absence of a robust innate immune response in rat neurons facilitates persistent infection of Borna disease virus in neuronal tissue #MMPMID23793543 Lin CC; Wu YJ; Heimrich B; Schwemmle M Cell Mol Life Sci 2013[Nov]; 70 (22): 4399-410 PMID23793543show ga Borna disease virus (BDV) persistently infects neurons of the central nervous system of various hosts, including rats. Since type I IFN-mediated antiviral response efficiently blocks BDV replication in primary rat embryo fibroblasts, it has been speculated that BDV is not effectively sensed by the host innate immune system in the nervous system. To test this assumption, organotypical rat hippocampal slice cultures were infected with BDV for up to 4 weeks. This resulted in the secretion of IFN and the up-regulation of IFN-stimulated genes. Using the rat Mx protein as a specific marker for IFN-induced gene expression, astrocytes and microglial cells were found to be Mx positive, whereas neurons, the major cell type in which BDV is replicating, lacked detectable levels of Mx protein. In uninfected cultures, neurons also remained Mx negative even after treatment with high concentrations of IFN-alpha. This non-responsiveness correlated with a lack of detectable nuclear translocation of both pSTAT1 and pSTAT2 in these cells. Consistently, neuronal dissemination of BDV was not prevented by treatment with IFN-alpha. These data suggest that the poor innate immune response in rat neurons renders this cell type highly susceptible to BDV infection even in the presence of exogenous IFN-alpha. Intriguingly, in contrast to rat neurons, IFN-alpha treatment of mouse neurons resulted in the up-regulation of Mx proteins and block of BDV replication, indicating species-specific differences in the type I IFN response of neurons between mice and rats. |Animals[MESH] |Astrocytes/cytology/metabolism[MESH] |Borna Disease/*immunology/metabolism/virology[MESH] |Borna disease virus/*physiology[MESH] |Hippocampus/cytology/metabolism[MESH] |Immunity, Innate/*physiology[MESH] |Interferon-alpha/pharmacology[MESH] |Mice[MESH] |Mice, Inbred BALB C[MESH] |Mice, Inbred C57BL[MESH] |Microglia/cytology/metabolism[MESH] |Myxovirus Resistance Proteins/metabolism[MESH] |Neurons/cytology/*metabolism/virology[MESH] |Phosphorylation[MESH] |Rats[MESH] |Rats, Inbred Lew[MESH] |Rats, Sprague-Dawley[MESH] |STAT1 Transcription Factor/metabolism[MESH] |STAT2 Transcription Factor/metabolism[MESH] |Up-Regulation/drug effects[MESH]Absence of a robust innate immune response in rat neurons facilitates (epmc).pdf DeepDyve Pubget Overpricing