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10.1093/carcin/bgt220 http://scihub22266oqcxt.onion/10.1093/carcin/bgt220 23784082!ä!23784082 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Carcinogenesis 2013 ; 34 (11): 2655-63 Nephropedia Template TP {{tp|p=23784082|t=2013. Activation of NF-kappaB by SOD2 promotes the aggressiveness of lung adenocarcinoma by modulating NKX2-1-mediated IKKbeta expression |pdf=|usr=}}{{23784082}} gab.com Text Activation of NF-kappaB by SOD2 promotes the aggressiveness of lung adenocarcinoma by modulating NKX2-1-mediated IKKbeta expression JO: Carcinogenesis http://www.kidney.de/pget.php?&tw=1&pmid=23784082 #FOAvip Magnesium superoxide dismutase (SOD2) has been shown to cause dysfunction of p53 transcriptional activity, whereas, in turn, SOD2 expression is regulated by p53 to modulate lung tumorigenesis. In this study, we found that the level of SOD2 expression in a panel of lung cancer cells was negatively correlated with that of NK2 homeobox 1 (NKX2-1) but was not associated with p53 status. Mechanistic studies indicated that a decrease in NKX2-1 caused by SOD2-activated IKKbeta transcription was achieved by derepression of binding of Sp1 to the IKKbeta promoter. Immunoprecipitation, glutathione S-transferase pull-down experiments and electrophoretic mobility shift assays demonstrated a direct interaction between NKX2-1 and Sp1, blocking Sp1-mediated IKKbeta transcription. SOD2-mediated nuclear factor-kappaB activation, via elevation of IKKbeta transcription, promoted anchorage-independent soft-agar growth, invasion and xenograft tumor formation, because of development of the epithelial-to-mesenchymal transition. The expression level of NKX2-1 messenger RNA was negatively associated with the extent of SOD immunostaining and the IKKbeta messenger RNA expression level in lung tumors. The extent of SOD2 immunostaining and IKKbeta messenger RNA levels may independently predict overall survival and relapse-free survival in lung adenocarcinoma patients. In summary, we found that SOD2 activates nuclear factor-kappaB signaling by increasing IKKbeta transcription, which results in progression of lung adenocarcinoma and poorer patient outcomes. We suggest that IKKbeta may potentially be targeted to improve outcomes in patients with SOD2-positive tumors. Twit Text FOAVip Activation of NF-kappaB by SOD2 promotes the aggressiveness of lung adenocarcinoma by modulating NKX2-1-mediated IKKbeta expression ????Carcinogenesis http://www.kidney.de/pget.php?&tw=1&pmid=23784082 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=23784082 #FOAvip English Wikipedia <ref>{{Cite pmid|23784082}}</ref> Activation of NF-kappaB by SOD2 promotes the aggressiveness of lung adenocarcinoma by modulating NKX2-1-mediated IKKbeta expression #MMPMID23784082 Chen PM; Wu TC; Wang YC; Cheng YW; Sheu GT; Chen CY; Lee H Carcinogenesis 2013[Nov]; 34 (11): 2655-63 PMID23784082show ga Magnesium superoxide dismutase (SOD2) has been shown to cause dysfunction of p53 transcriptional activity, whereas, in turn, SOD2 expression is regulated by p53 to modulate lung tumorigenesis. In this study, we found that the level of SOD2 expression in a panel of lung cancer cells was negatively correlated with that of NK2 homeobox 1 (NKX2-1) but was not associated with p53 status. Mechanistic studies indicated that a decrease in NKX2-1 caused by SOD2-activated IKKbeta transcription was achieved by derepression of binding of Sp1 to the IKKbeta promoter. Immunoprecipitation, glutathione S-transferase pull-down experiments and electrophoretic mobility shift assays demonstrated a direct interaction between NKX2-1 and Sp1, blocking Sp1-mediated IKKbeta transcription. SOD2-mediated nuclear factor-kappaB activation, via elevation of IKKbeta transcription, promoted anchorage-independent soft-agar growth, invasion and xenograft tumor formation, because of development of the epithelial-to-mesenchymal transition. The expression level of NKX2-1 messenger RNA was negatively associated with the extent of SOD immunostaining and the IKKbeta messenger RNA expression level in lung tumors. The extent of SOD2 immunostaining and IKKbeta messenger RNA levels may independently predict overall survival and relapse-free survival in lung adenocarcinoma patients. In summary, we found that SOD2 activates nuclear factor-kappaB signaling by increasing IKKbeta transcription, which results in progression of lung adenocarcinoma and poorer patient outcomes. We suggest that IKKbeta may potentially be targeted to improve outcomes in patients with SOD2-positive tumors. |Adenocarcinoma/metabolism/mortality/*pathology[MESH] |Animals[MESH] |Blotting, Western[MESH] |Cell Adhesion[MESH] |Cell Movement[MESH] |Cell Proliferation[MESH] |Chromatin Immunoprecipitation[MESH] |Electrophoretic Mobility Shift Assay[MESH] |Epithelial-Mesenchymal Transition[MESH] |Female[MESH] |Humans[MESH] |I-kappa B Kinase/*genetics/metabolism[MESH] |Immunoenzyme Techniques[MESH] |Luciferases/metabolism[MESH] |Lung Neoplasms/metabolism/mortality/*pathology[MESH] |Mice[MESH] |Mice, Inbred BALB C[MESH] |Mice, Nude[MESH] |NF-kappa B/genetics/*metabolism[MESH] |Nuclear Proteins/genetics/*metabolism[MESH] |Promoter Regions, Genetic[MESH] |RNA, Messenger/genetics[MESH] |Real-Time Polymerase Chain Reaction[MESH] |Reverse Transcriptase Polymerase Chain Reaction[MESH] |Superoxide Dismutase/genetics/*metabolism[MESH] |Thyroid Nuclear Factor 1[MESH] |Transcription Factors/genetics/*metabolism[MESH] |Tumor Cells, Cultured[MESH]Activation of NF-kappaB by SOD2 promotes the aggressiveness of lung ad(epmc).pdf DeepDyve Pubget Overpricing