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Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Hong+Kong+Med+J 2013 ; 19 Suppl 4 (ä): 29-35 Nephropedia Template TP
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Role of cyclooxygenase-2 in H5N1 viral pathogenesis and the potential use of its inhibitors #MMPMID23775184
Lee MY; Cheung CY; Peiris JS
Hong Kong Med J 2013[Jun]; 19 Suppl 4 (ä): 29-35 PMID23775184show ga
1. Cyclooxygenase-2 (COX-2), along with TNF-alpha and other proinflammatory cytokines, was hyperinduced in H5N1- infected macrophages in vitro and in epithelial cells of autopsied lung tissues of infected patients. 2. The COX-2 mediated amplification of the proinflammatory response is rapid, and the effects elicited by the H5N1-triggered proinflammatory cascade are broader than those arising from direct viral infection. 3. Selective COX-2 inhibitors suppress the H5N1- hyperinduced cytokines in the proinflammatory cascade.
|Antiviral Agents/*pharmacology[MESH]
|Cell Line, Tumor[MESH]
|Cyclooxygenase 2 Inhibitors/*pharmacology[MESH]
|Cyclooxygenase 2/drug effects[MESH]
|Cytokines/metabolism[MESH]
|Epithelial Cells/metabolism/virology[MESH]
|Humans[MESH]
|Inflammation/drug therapy/virology[MESH]
|Influenza A Virus, H5N1 Subtype/drug effects/*enzymology/isolation & purification[MESH]