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pmid23775184      Hong+Kong+Med+J 2013 ; 19 Suppl 4 (ä): 29-35
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  • Role of cyclooxygenase-2 in H5N1 viral pathogenesis and the potential use of its inhibitors #MMPMID23775184
  • Lee MY; Cheung CY; Peiris JS
  • Hong Kong Med J 2013[Jun]; 19 Suppl 4 (ä): 29-35 PMID23775184show ga
  • 1. Cyclooxygenase-2 (COX-2), along with TNF-alpha and other proinflammatory cytokines, was hyperinduced in H5N1- infected macrophages in vitro and in epithelial cells of autopsied lung tissues of infected patients. 2. The COX-2 mediated amplification of the proinflammatory response is rapid, and the effects elicited by the H5N1-triggered proinflammatory cascade are broader than those arising from direct viral infection. 3. Selective COX-2 inhibitors suppress the H5N1- hyperinduced cytokines in the proinflammatory cascade.
  • |Antiviral Agents/*pharmacology[MESH]
  • |Cell Line, Tumor[MESH]
  • |Cyclooxygenase 2 Inhibitors/*pharmacology[MESH]
  • |Cyclooxygenase 2/drug effects[MESH]
  • |Cytokines/metabolism[MESH]
  • |Epithelial Cells/metabolism/virology[MESH]
  • |Humans[MESH]
  • |Inflammation/drug therapy/virology[MESH]
  • |Influenza A Virus, H5N1 Subtype/drug effects/*enzymology/isolation & purification[MESH]
  • |Influenza, Human/drug therapy/*enzymology/virology[MESH]
  • |Lung/cytology/virology[MESH]
  • |Macrophages/metabolism/virology[MESH]


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