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10.1007/s00467-013-2501-0 http://scihub22266oqcxt.onion/10.1007/s00467-013-2501-0 23760992!ä!23760992 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Pediatr+Nephrol 2014 ; 29 (5): 815-23; quiz 821 Nephropedia Template TP {{tp|p=23760992|t=2014. Targeted therapy aimed at cancer stem cells: Wilms tumor as an example |pdf=|usr=}}{{23760992}} gab.com Text Targeted therapy aimed at cancer stem cells: Wilms tumor as an example JO: Pediatr Nephrol http://www.kidney.de/pget.php?&tw=1&pmid=23760992 #FOAvip Wilms' tumor (WT), a common renal pediatric solid tumor, serves as a model for a malignancy formed by renal precursor cells that have failed to differentiate properly. Here we review recent evidence showing that the tumors' heterogeneous cell population contains a small fraction of cancer stem cells (CSC) identified by two markers: Neural Cell Adhesion Molecule 1 (NCAM1) expression and Aldehyde dehydrogenase 1 (ALDH1) enzymatic activity. In vivo studies show these CSCs to both self-renew and differentiate to give rise to all tumor components. Similar to other malignancies, the identification of a specific CSC fraction has allowed the examination of a novel targeted therapy, aimed at eradicating the CSC population. The loss of CSCs abolishes the tumor's ability to sustain and propagate, hence, causing tumor degradation with minimal damage to normal tissue. Twit Text FOAVip Targeted therapy aimed at cancer stem cells: Wilms tumor as an example ????Pediatr Nephrol http://www.kidney.de/pget.php?&tw=1&pmid=23760992 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=23760992 #FOAvip English Wikipedia <ref>{{Cite pmid|23760992}}</ref> Targeted therapy aimed at cancer stem cells: Wilms tumor as an example #MMPMID23760992 Shukrun R; Pode Shakked N; Dekel B Pediatr Nephrol 2014[May]; 29 (5): 815-23; quiz 821 PMID23760992show ga Wilms' tumor (WT), a common renal pediatric solid tumor, serves as a model for a malignancy formed by renal precursor cells that have failed to differentiate properly. Here we review recent evidence showing that the tumors' heterogeneous cell population contains a small fraction of cancer stem cells (CSC) identified by two markers: Neural Cell Adhesion Molecule 1 (NCAM1) expression and Aldehyde dehydrogenase 1 (ALDH1) enzymatic activity. In vivo studies show these CSCs to both self-renew and differentiate to give rise to all tumor components. Similar to other malignancies, the identification of a specific CSC fraction has allowed the examination of a novel targeted therapy, aimed at eradicating the CSC population. The loss of CSCs abolishes the tumor's ability to sustain and propagate, hence, causing tumor degradation with minimal damage to normal tissue. |Aldehyde Dehydrogenase 1 Family[MESH] |CD56 Antigen/biosynthesis/genetics[MESH] |Child[MESH] |Humans[MESH] |Isoenzymes/biosynthesis/genetics[MESH] |Kidney Neoplasms/pathology/*therapy[MESH] |Neoplastic Stem Cells/*physiology[MESH] |Retinal Dehydrogenase/biosynthesis/genetics[MESH]Targeted therapy aimed at cancer stem cells: Wilms tumor as an exampl(epmc).pdf DeepDyve Pubget Overpricing