Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.4103/0976-500X.110892 http://scihub22266oqcxt.onion/10.4103/0976-500X.110892 23759957!3669570!23759957     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=23759957&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       J+Pharmacol+Pharmacother 2013 ; 4 (2): 116-24 Nephropedia Template TP {{tp|p=23759957|t=2013. Assessment of proarrhythmic activity of chloroquine in in vivo and ex vivo rabbit models |pdf=|usr=}}{{23759957}} gab.com Text Assessment of proarrhythmic activity of chloroquine in in vivo and ex vivo rabbit models JO: J Pharmacol Pharmacother http://www.kidney.de/pget.php?&tw=1&pmid=23759957 #FOAvip OBJECTIVES: To evaluate the prolongation of ventricular repolarization and proarrhythmic activity of antimalarial drug chloroquine in two rabbit proarrhythmia models viz., in vivo alpha1 adrenoceptor-stimulated anesthetized rabbit and ex vivo isolated Langendorff rabbit heart using clofilium as standard proarrhythmic agent. MATERIALS AND METHODS: In the in vivo model, three groups of rabbits, anesthetized by pentobarbitone sodium and alpha-chloralose, sensitized with alpha1 agonist methoxamine followed by either continuous infusion of saline (control) or clofilium (3 mg/kg) or chloroquine (21 mg/kg) for 30 min. In ex vivo model, rabbit hearts were perfused with clofilium (10 muM) or chloroquine (300 muM) continuously after priming along with methoxamine, acetylcholine chloride and propranolol hydrochloride. RESULTS: In these models, prolongation of repolarization during alpha1-adrenoceptor stimulation produced early after depolarization (EAD) and Torsade de pointes (TdP). Saline infusion did not induce any abnormality in the animals. Clofilium caused expected changes in the electrocardiogram in both the models including TdP (50.0% in in vivo and 66.67% in ex vivo). Chloroquine caused decrease in heart rate and increase in the corrected QT (QTc) interval in both the models. Further, apart from different stages of arrhythmia, TdP was evident in 33.33% in ex vivo model, whereas no TdP was observed in in vivo model. CONCLUSIONS: The results indicated that proarrhythmic potential of chloroquine and clofilium was well evaluated in both the models; moreover, both the models can be used to assess the proarrhythmic potential of the new drug candidates. Twit Text FOAVip Assessment of proarrhythmic activity of chloroquine in in vivo and ex vivo rabbit models ????J Pharmacol Pharmacother http://www.kidney.de/pget.php?&tw=1&pmid=23759957 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=23759957 #FOAvip English Wikipedia <ref>{{Cite pmid|23759957}}</ref> Assessment of proarrhythmic activity of chloroquine in in vivo and ex vivo rabbit models #MMPMID23759957 Khobragade SB; Gupta P; Gurav P; Chaudhari G; Gatne MM; Shingatgeri VM J Pharmacol Pharmacother 2013[Apr]; 4 (2): 116-24 PMID23759957show ga OBJECTIVES: To evaluate the prolongation of ventricular repolarization and proarrhythmic activity of antimalarial drug chloroquine in two rabbit proarrhythmia models viz., in vivo alpha1 adrenoceptor-stimulated anesthetized rabbit and ex vivo isolated Langendorff rabbit heart using clofilium as standard proarrhythmic agent. MATERIALS AND METHODS: In the in vivo model, three groups of rabbits, anesthetized by pentobarbitone sodium and alpha-chloralose, sensitized with alpha1 agonist methoxamine followed by either continuous infusion of saline (control) or clofilium (3 mg/kg) or chloroquine (21 mg/kg) for 30 min. In ex vivo model, rabbit hearts were perfused with clofilium (10 muM) or chloroquine (300 muM) continuously after priming along with methoxamine, acetylcholine chloride and propranolol hydrochloride. RESULTS: In these models, prolongation of repolarization during alpha1-adrenoceptor stimulation produced early after depolarization (EAD) and Torsade de pointes (TdP). Saline infusion did not induce any abnormality in the animals. Clofilium caused expected changes in the electrocardiogram in both the models including TdP (50.0% in in vivo and 66.67% in ex vivo). Chloroquine caused decrease in heart rate and increase in the corrected QT (QTc) interval in both the models. Further, apart from different stages of arrhythmia, TdP was evident in 33.33% in ex vivo model, whereas no TdP was observed in in vivo model. CONCLUSIONS: The results indicated that proarrhythmic potential of chloroquine and clofilium was well evaluated in both the models; moreover, both the models can be used to assess the proarrhythmic potential of the new drug candidates. ?Assessment of proarrhythmic activity of chloroquine in in vivo and ex (epmc).pdf DeepDyve Pubget Overpricing