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10.3892/ol.2013.1259 http://scihub22266oqcxt.onion/10.3892/ol.2013.1259 23759954!3678863!23759954     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=23759954&cmd=llinks): Failed to open stream: HTTP request failed! 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Mefloquine induces cell death in prostate cancer cells and provides a potential novel treatment strategy in vivo |pdf=|usr=}}{{23759954}} gab.com Text Mefloquine induces cell death in prostate cancer cells and provides a potential novel treatment strategy in vivo JO: Oncol Lett http://www.kidney.de/pget.php?&tw=1&pmid=23759954 #FOAvip Mefloquine (MQ) is currently in clinical use as a prophylactic treatment for malaria. Previous studies have shown that MQ induces oxidative stress in vitro. The present study investigated the anticancer effects of MQ treatment in PC3 cells. The cell viability was evaluated using sulphorhodamine-B (SRB) staining, while annexin V and propidium iodide (PI) were used as an assay for cell death. Reactive oxygen species (ROS) formation was detected with 2',7'-dichlorofluorescein-diacetate (DCFH-DA), a sensitive intracellular probe, and the alteration of cellular status was defined by trypan blue staining. The results of the present study indicated that MQ has a high cytotoxicity that causes cell death in PC3 cells. MQ markedly inhibited the PC3 cells through non-apoptotic cell death. MQ also induced significant ROS production. The MQ treatment mediated G1 cell cycle arrest and cyclin D1 accumulation through p21 upregulation in the PC3 cells. Moreover, the use of MQ improved the survival of the treatment group compared with the control group in the experimental mice. The present study indicates that MQ possesses potential therapeutic efficacy for the treatment of prostate cancer (PCa) in vivo. These findings provide insights that may aid the further optimization and application of new and existing therapeutic options. Twit Text FOAVip Mefloquine induces cell death in prostate cancer cells and provides a potential novel treatment strategy in vivo ????Oncol Lett http://www.kidney.de/pget.php?&tw=1&pmid=23759954 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=23759954 #FOAvip English Wikipedia <ref>{{Cite pmid|23759954}}</ref> Mefloquine induces cell death in prostate cancer cells and provides a potential novel treatment strategy in vivo #MMPMID23759954 Yan KH; Lin YW; Hsiao CH; Wen YC; Lin KH; Liu CC; Hsieh MC; Yao CJ; Yan MD; Lai GM; Chuang SE; Lee LM Oncol Lett 2013[May]; 5 (5): 1567-1571 PMID23759954show ga Mefloquine (MQ) is currently in clinical use as a prophylactic treatment for malaria. Previous studies have shown that MQ induces oxidative stress in vitro. The present study investigated the anticancer effects of MQ treatment in PC3 cells. The cell viability was evaluated using sulphorhodamine-B (SRB) staining, while annexin V and propidium iodide (PI) were used as an assay for cell death. Reactive oxygen species (ROS) formation was detected with 2',7'-dichlorofluorescein-diacetate (DCFH-DA), a sensitive intracellular probe, and the alteration of cellular status was defined by trypan blue staining. The results of the present study indicated that MQ has a high cytotoxicity that causes cell death in PC3 cells. MQ markedly inhibited the PC3 cells through non-apoptotic cell death. MQ also induced significant ROS production. The MQ treatment mediated G1 cell cycle arrest and cyclin D1 accumulation through p21 upregulation in the PC3 cells. Moreover, the use of MQ improved the survival of the treatment group compared with the control group in the experimental mice. The present study indicates that MQ possesses potential therapeutic efficacy for the treatment of prostate cancer (PCa) in vivo. These findings provide insights that may aid the further optimization and application of new and existing therapeutic options. äMefloquine induces cell death in prostate cancer cells and provides a (epmc).pdf DeepDyve Pubget Overpricing