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10.1021/cn400094w http://scihub22266oqcxt.onion/10.1021/cn400094w 23758534/?report=reader!3750679!23758534     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       ACS+Chem+Neurosci 2013 ; 4 (8): 1151-62 Nephropedia Template TP {{tp|p=23758534|t=2013. Neuroprotective properties and mechanisms of resveratrol in in vitro and in vivo experimental cerebral stroke models |pdf=|usr=}}{{23758534}} gab.com Text Neuroprotective properties and mechanisms of resveratrol in in vitro and in vivo experimental cerebral stroke models JO: ACS Chem Neurosci http://www.kidney.de/pget.php?&tw=1&pmid=23758534 #FOAvip Resveratrol, a natural stilbene present at relatively high concentrations in grape skin and seeds and red wine, is known for its purported antioxidant activity in the vascular and nervous systems. In contrast to its direct antioxidant role within the central nervous system, recent research supports a protective mechanism through increasing endogenous cellular antioxidant defenses, which triggers a cascade of parallel neuroprotective pathways. A growing body of in vitro and in vivo evidence indicates that resveratrol acts through multiple pathways and reduces ischemic damage in vital organs, such as the heart and the brain, in various rodent models. Most of the protective biological actions of resveratrol have been associated with its antioxidative, anti-inflammatory, and antiapoptotic properties and other indirect pathways. Continued public interest and increasing resveratrol supplements on the market warrant a review of the available in vitro and in vivo science reported in the stroke-related literature. Rigorous clinical trials evaluating the effects of resveratrol in stroke are absent, though the general population consumption appears to be relatively safe. Resveratrol has shown potential for treating stroke in laboratory animals and in vitro human cell studies, yet there is still a need for human research in preclinical settings. This review summarizes many of the findings on the neuroprotective potential of resveratrol in cerebral stroke, focusing on both the in vitro and in vivo experimental models and some proposed mechanisms of action. Twit Text FOAVip Neuroprotective properties and mechanisms of resveratrol in in vitro and in vivo experimental cerebral stroke models ????ACS Chem Neurosci http://www.kidney.de/pget.php?&tw=1&pmid=23758534 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=23758534 #FOAvip English Wikipedia <ref>{{Cite pmid|23758534}}</ref> Neuroprotective properties and mechanisms of resveratrol in in vitro and in vivo experimental cerebral stroke models #MMPMID23758534 Singh N; Agrawal M; Dore S ACS Chem Neurosci 2013[Aug]; 4 (8): 1151-62 PMID23758534show ga Resveratrol, a natural stilbene present at relatively high concentrations in grape skin and seeds and red wine, is known for its purported antioxidant activity in the vascular and nervous systems. In contrast to its direct antioxidant role within the central nervous system, recent research supports a protective mechanism through increasing endogenous cellular antioxidant defenses, which triggers a cascade of parallel neuroprotective pathways. A growing body of in vitro and in vivo evidence indicates that resveratrol acts through multiple pathways and reduces ischemic damage in vital organs, such as the heart and the brain, in various rodent models. Most of the protective biological actions of resveratrol have been associated with its antioxidative, anti-inflammatory, and antiapoptotic properties and other indirect pathways. Continued public interest and increasing resveratrol supplements on the market warrant a review of the available in vitro and in vivo science reported in the stroke-related literature. Rigorous clinical trials evaluating the effects of resveratrol in stroke are absent, though the general population consumption appears to be relatively safe. Resveratrol has shown potential for treating stroke in laboratory animals and in vitro human cell studies, yet there is still a need for human research in preclinical settings. This review summarizes many of the findings on the neuroprotective potential of resveratrol in cerebral stroke, focusing on both the in vitro and in vivo experimental models and some proposed mechanisms of action. |Animals[MESH] |Anti-Inflammatory Agents, Non-Steroidal/metabolism[MESH] |Apoptosis/drug effects[MESH] |Biological Availability[MESH] |Brain/*drug effects[MESH] |Disease Models, Animal[MESH] |Drug Evaluation, Preclinical[MESH] |Gerbillinae[MESH] |Humans[MESH] |Mice[MESH] |Neuroprotective Agents/*metabolism/pharmacokinetics[MESH] |Oxidative Stress/drug effects[MESH] |Rats[MESH] |Resveratrol[MESH] |Stilbenes/*metabolism/pharmacokinetics[MESH]Neuroprotective properties and mechanisms of resveratrol in in vitro a(epmc).pdf DeepDyve Pubget Overpricing