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http://scihub22266oqcxt.onion/ 23746243!?!23746243 Warning: Undefined variable $yww in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 538 Warning: Undefined variable $yww in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 538       Xi+Bao+Yu+Fen+Zi+Mian+Yi+Xue+Za+Zhi 2013 ; 29 (6): 593-6 Nephropedia Template TP {{tp|p=23746243|t=2013. Angiotensin-(1-7) inhibits hypoxia-induced renal tubular epithelial-to-mesenchymal transition in rats |pdf=|usr=}}{{23746243}} gab.com Text Angiotensin-(1-7) inhibits hypoxia-induced renal tubular epithelial-to-mesenchymal transition in rats JO: Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi http://www.kidney.de/pget.php?&tw=1&pmid=23746243 #FOAvip OBJECTIVE: To investigate the effect of angiotensin-(1-7) [Ang(1-7)] on the transdifferentiation of normal rat kidney proximal tubular epithelia cells (NRK52E) under hypoxic condition induced by cobaltous chloride (Co) and the underlying mechanism. METHODS: NRK52E cells were divided into control group, Co group, Co+Ang-(1-7) group and Ang-(1-7) group and cultured for 6 d. Expression levels of hypoxia-inducible factor-1alpha (HIF-lalpha) and alpha-smooth muscle actin (alpha-SMA) were detected by immunocytochemistry. Immunohistochemistry and Western blotting were used to determine the expression of p-ERK1/2 and ELISA to measure the content of collagen type 1 (Col I) in the culture supernatant. RESULTS: Compared with the control group, the expressions of HIF-lalpha, alpha-SMA, Col Iand p-ERK1/2 in the Co group and the Co+Ang-(1-7) group increased significantly (P<0.05) 6 d later. Compared with the Co group, the expressions of HIF-lalpha, alpha-SMA, Col Iand p-ERK1/2 in the Co+Ang-(1-7) group decreased significantly (P<0.05). CONCLUSION: Ang-(1-7) can inhibit Co-induced rats' tubular epithelial-to-mesenchymal transition and reduce the production of extracellular matrix. Inhibition of ERK1/2 pathway may play an important role in this process. Twit Text FOAVip Angiotensin-(1-7) inhibits hypoxia-induced renal tubular epithelial-to-mesenchymal transition in rats ????Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi http://www.kidney.de/pget.php?&tw=1&pmid=23746243 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=23746243 #FOAvip English Wikipedia <ref>{{Cite pmid|23746243}}</ref> Angiotensin-(1-7) inhibits hypoxia-induced renal tubular epithelial-to-mesenchymal transition in rats #MMPMID23746243 Ren T; He H; Yu X; Fan J; Tan J; Liu J Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 2013[Jun]; 29 (6): 593-6 PMID23746243show ga OBJECTIVE: To investigate the effect of angiotensin-(1-7) [Ang(1-7)] on the transdifferentiation of normal rat kidney proximal tubular epithelia cells (NRK52E) under hypoxic condition induced by cobaltous chloride (Co) and the underlying mechanism. METHODS: NRK52E cells were divided into control group, Co group, Co+Ang-(1-7) group and Ang-(1-7) group and cultured for 6 d. Expression levels of hypoxia-inducible factor-1alpha (HIF-lalpha) and alpha-smooth muscle actin (alpha-SMA) were detected by immunocytochemistry. Immunohistochemistry and Western blotting were used to determine the expression of p-ERK1/2 and ELISA to measure the content of collagen type 1 (Col I) in the culture supernatant. RESULTS: Compared with the control group, the expressions of HIF-lalpha, alpha-SMA, Col Iand p-ERK1/2 in the Co group and the Co+Ang-(1-7) group increased significantly (P<0.05) 6 d later. Compared with the Co group, the expressions of HIF-lalpha, alpha-SMA, Col Iand p-ERK1/2 in the Co+Ang-(1-7) group decreased significantly (P<0.05). CONCLUSION: Ang-(1-7) can inhibit Co-induced rats' tubular epithelial-to-mesenchymal transition and reduce the production of extracellular matrix. Inhibition of ERK1/2 pathway may play an important role in this process. |*Hypoxia[MESH] |Actins/metabolism[MESH] |Angiotensin I/*pharmacology[MESH] |Animals[MESH] |Cell Line[MESH] |Cobalt/pharmacology[MESH] |Collagen Type I/metabolism[MESH] |Epithelial-Mesenchymal Transition/*drug effects[MESH] |Hypoxia-Inducible Factor 1, alpha Subunit/metabolism[MESH] |Kidney Tubules, Proximal/*drug effects/*pathology[MESH] |Mitogen-Activated Protein Kinase 1/metabolism[MESH] |Mitogen-Activated Protein Kinase 3/metabolism[MESH] |Peptide Fragments/*pharmacology[MESH] Angiotensin-(1-7) inhibits hypoxia-induced renal tubular epithelial-(epmc).pdf DeepDyve Pubget Overpricing