Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1002/cphy.c100069 http://scihub22266oqcxt.onion/10.1002/cphy.c100069 23728973!3919066!23728973     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Compr+Physiol 2012 ; 2 (1): 141-219 Nephropedia Template TP {{tp|p=23728973|t=2012. Peripheral chemoreceptors: function and plasticity of the carotid body |pdf=|usr=}}{{23728973}} gab.com Text Peripheral chemoreceptors: function and plasticity of the carotid body JO: Compr Physiol http://www.kidney.de/pget.php?&tw=1&pmid=23728973 #FOAvip The discovery of the sensory nature of the carotid body dates back to the beginning of the 20th century. Following these seminal discoveries, research into carotid body mechanisms moved forward progressively through the 20th century, with many descriptions of the ultrastructure of the organ and stimulus-response measurements at the level of the whole organ. The later part of 20th century witnessed the first descriptions of the cellular responses and electrophysiology of isolated and cultured type I and type II cells, and there now exist a number of testable hypotheses of chemotransduction. The goal of this article is to provide a comprehensive review of current concepts on sensory transduction and transmission of the hypoxic stimulus at the carotid body with an emphasis on integrating cellular mechanisms with the whole organ responses and highlighting the gaps or discrepancies in our knowledge. It is increasingly evident that in addition to hypoxia, the carotid body responds to a wide variety of blood-borne stimuli, including reduced glucose and immune-related cytokines and we therefore also consider the evidence for a polymodal function of the carotid body and its implications. It is clear that the sensory function of the carotid body exhibits considerable plasticity in response to the chronic perturbations in environmental O2 that is associated with many physiological and pathological conditions. The mechanisms and consequences of carotid body plasticity in health and disease are discussed in the final sections of this article. Twit Text FOAVip Peripheral chemoreceptors: function and plasticity of the carotid body ????Compr Physiol http://www.kidney.de/pget.php?&tw=1&pmid=23728973 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=23728973 #FOAvip English Wikipedia <ref>{{Cite pmid|23728973}}</ref> Peripheral chemoreceptors: function and plasticity of the carotid body #MMPMID23728973 Kumar P; Prabhakar NR Compr Physiol 2012[Jan]; 2 (1): 141-219 PMID23728973show ga The discovery of the sensory nature of the carotid body dates back to the beginning of the 20th century. Following these seminal discoveries, research into carotid body mechanisms moved forward progressively through the 20th century, with many descriptions of the ultrastructure of the organ and stimulus-response measurements at the level of the whole organ. The later part of 20th century witnessed the first descriptions of the cellular responses and electrophysiology of isolated and cultured type I and type II cells, and there now exist a number of testable hypotheses of chemotransduction. The goal of this article is to provide a comprehensive review of current concepts on sensory transduction and transmission of the hypoxic stimulus at the carotid body with an emphasis on integrating cellular mechanisms with the whole organ responses and highlighting the gaps or discrepancies in our knowledge. It is increasingly evident that in addition to hypoxia, the carotid body responds to a wide variety of blood-borne stimuli, including reduced glucose and immune-related cytokines and we therefore also consider the evidence for a polymodal function of the carotid body and its implications. It is clear that the sensory function of the carotid body exhibits considerable plasticity in response to the chronic perturbations in environmental O2 that is associated with many physiological and pathological conditions. The mechanisms and consequences of carotid body plasticity in health and disease are discussed in the final sections of this article. |Carbon Dioxide/blood[MESH] |Cardiovascular Diseases/physiopathology[MESH] |Carotid Body/blood supply/cytology/*physiology[MESH] |Cell Hypoxia/physiology[MESH] |Chemoreceptor Cells/*physiology[MESH] |Humans[MESH] |Mitochondria/physiology[MESH] |Neuronal Plasticity/*physiology[MESH] |Neurotransmitter Agents/metabolism[MESH] |Oxygen/blood[MESH] |Partial Pressure[MESH] |Regional Blood Flow[MESH] |Signal Transduction/physiology[MESH]Peripheral chemoreceptors: function and plasticity of the carotid body(epmc).pdf DeepDyve Pubget Overpricing