Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1126/scitranslmed.3005765 http://scihub22266oqcxt.onion/10.1126/scitranslmed.3005765 23698380!ä!23698380 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sci+Transl+Med 2013 ; 5 (186): 186ra67 Nephropedia Template TP {{tp|p=23698380|t=2013. Impaired sphingolipid synthesis in the respiratory tract induces airway hyperreactivity |pdf=|usr=}}{{23698380}} gab.com Text Impaired sphingolipid synthesis in the respiratory tract induces airway hyperreactivity JO: Sci Transl Med http://www.kidney.de/pget.php?&tw=1&pmid=23698380 #FOAvip Asthma is a clinically heterogeneous genetic disease, and its pathogenesis is incompletely understood. Genome-wide association studies link ORM (yeast)-Like protein isoform 3 [corrected] (ORMDL3), a member of the ORM gene family, to nonallergic childhood-onset asthma. Orm proteins negatively regulate sphingolipid (SL) synthesis by acting as homeostatic regulators of serine palmitoyl-CoA transferase (SPT), the rate-limiting enzyme of de novo SL synthesis, but it is not known how SPT activity or SL synthesis is related to asthma. The present study analyzes the effect of decreased de novo SL synthesis in the lung on airway reactivity after administration of myriocin, an inhibitor of SPT, and in SPT heterozygous knockout mice. We show that, in both models, decreased de novo SL synthesis increases bronchial reactivity in the absence of inflammation. Decreased SPT activity affected intracellular magnesium homeostasis and altered the bronchial sensitivity to magnesium. This functionally links decreased de novo SL synthesis to asthma and so identifies this metabolic pathway as a potential target for therapeutic interventions. Twit Text FOAVip Impaired sphingolipid synthesis in the respiratory tract induces airway hyperreactivity ????Sci Transl Med http://www.kidney.de/pget.php?&tw=1&pmid=23698380 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=23698380 #FOAvip English Wikipedia <ref>{{Cite pmid|23698380}}</ref> Impaired sphingolipid synthesis in the respiratory tract induces airway hyperreactivity #MMPMID23698380 Worgall TS; Veerappan A; Sung B; Kim BI; Weiner E; Bholah R; Silver RB; Jiang XC; Worgall S Sci Transl Med 2013[May]; 5 (186): 186ra67 PMID23698380show ga Asthma is a clinically heterogeneous genetic disease, and its pathogenesis is incompletely understood. Genome-wide association studies link ORM (yeast)-Like protein isoform 3 [corrected] (ORMDL3), a member of the ORM gene family, to nonallergic childhood-onset asthma. Orm proteins negatively regulate sphingolipid (SL) synthesis by acting as homeostatic regulators of serine palmitoyl-CoA transferase (SPT), the rate-limiting enzyme of de novo SL synthesis, but it is not known how SPT activity or SL synthesis is related to asthma. The present study analyzes the effect of decreased de novo SL synthesis in the lung on airway reactivity after administration of myriocin, an inhibitor of SPT, and in SPT heterozygous knockout mice. We show that, in both models, decreased de novo SL synthesis increases bronchial reactivity in the absence of inflammation. Decreased SPT activity affected intracellular magnesium homeostasis and altered the bronchial sensitivity to magnesium. This functionally links decreased de novo SL synthesis to asthma and so identifies this metabolic pathway as a potential target for therapeutic interventions. |Airway Remodeling/drug effects[MESH] |Animals[MESH] |Bronchial Hyperreactivity/complications/*metabolism/*pathology/physiopathology[MESH] |Fatty Acids, Monounsaturated/pharmacology[MESH] |Female[MESH] |Homeostasis/drug effects[MESH] |Lung/enzymology/*metabolism/*pathology/physiopathology[MESH] |Magnesium/metabolism[MESH] |Mice[MESH] |Mice, Inbred BALB C[MESH] |Mucus/metabolism[MESH] |Pneumonia/complications/pathology[MESH] |Serine C-Palmitoyltransferase/metabolism[MESH]Impaired sphingolipid synthesis in the respiratory tract induces airwa(epmc).pdf DeepDyve Pubget Overpricing