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10.1007/s00284-013-0381-y

http://scihub22266oqcxt.onion/10.1007/s00284-013-0381-y
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23680974!ä!23680974

suck abstract from ncbi


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pmid23680974      Curr+Microbiol 2013 ; 67 (4): 431-6
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  • Immunologic mechanism of Patchouli alcohol anti-H1N1 influenza virus may through regulation of the RLH signal pathway in vitro #MMPMID23680974
  • Wu XL; Ju DH; Chen J; Yu B; Liu KL; He JX; Dai CQ; Wu S; Chang Z; Wang YP; Chen XY
  • Curr Microbiol 2013[Oct]; 67 (4): 431-6 PMID23680974show ga
  • Patchouli alcohol (PA) is a kind of methanol extracted from traditional Chinese medicine Pogostemonis Herba. Our research aimed to observe the anti-influenza virus role of PA in vitro. 16HBE (human respiratory epithelial cell) was infected by H1N1 (A/FM1/1/47) to set the cell model. Then the 16HBE was co-cultivated with three kinds of immune cells: dendritic cells, macrophages, and monocytes, PA (the concentration is 10 mug/mL) was added as a treatment intervention for 24 h. The immune cells and the supernate were collected for RT-PCR and ELISA detection related to RLH (RIG-1-like helicases) pathway. Results showed that the IL-4 and IFN-gamma in supernate were increased after H1N1 infection, and the PA treatment suppressed the expression of cytokines and the mRNA of RLH pathway. PA anti-influenza virus may through regulate the RLH singal pathway.
  • |Antiviral Agents/*pharmacology[MESH]
  • |Dendritic Cells/drug effects/immunology[MESH]
  • |Drugs, Chinese Herbal/*pharmacology[MESH]
  • |Humans[MESH]
  • |Immunologic Factors/*pharmacology[MESH]
  • |Influenza A Virus, H1N1 Subtype/*drug effects/physiology[MESH]
  • |Influenza, Human/drug therapy/enzymology/*immunology/virology[MESH]
  • |Interferon-gamma/genetics/immunology[MESH]
  • |Interleukin-4/genetics/immunology[MESH]
  • |Macrophages/drug effects/immunology[MESH]
  • |RNA Helicases/genetics/*immunology[MESH]
  • |Sesquiterpenes/*pharmacology[MESH]


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