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Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Curr+Microbiol 2013 ; 67 (4): 431-6 Nephropedia Template TP
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Immunologic mechanism of Patchouli alcohol anti-H1N1 influenza virus may through regulation of the RLH signal pathway in vitro #MMPMID23680974
Wu XL; Ju DH; Chen J; Yu B; Liu KL; He JX; Dai CQ; Wu S; Chang Z; Wang YP; Chen XY
Curr Microbiol 2013[Oct]; 67 (4): 431-6 PMID23680974show ga
Patchouli alcohol (PA) is a kind of methanol extracted from traditional Chinese medicine Pogostemonis Herba. Our research aimed to observe the anti-influenza virus role of PA in vitro. 16HBE (human respiratory epithelial cell) was infected by H1N1 (A/FM1/1/47) to set the cell model. Then the 16HBE was co-cultivated with three kinds of immune cells: dendritic cells, macrophages, and monocytes, PA (the concentration is 10 mug/mL) was added as a treatment intervention for 24 h. The immune cells and the supernate were collected for RT-PCR and ELISA detection related to RLH (RIG-1-like helicases) pathway. Results showed that the IL-4 and IFN-gamma in supernate were increased after H1N1 infection, and the PA treatment suppressed the expression of cytokines and the mRNA of RLH pathway. PA anti-influenza virus may through regulate the RLH singal pathway.
|Antiviral Agents/*pharmacology[MESH]
|Dendritic Cells/drug effects/immunology[MESH]
|Drugs, Chinese Herbal/*pharmacology[MESH]
|Humans[MESH]
|Immunologic Factors/*pharmacology[MESH]
|Influenza A Virus, H1N1 Subtype/*drug effects/physiology[MESH]