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10.1038/aps.2013.26 http://scihub22266oqcxt.onion/10.1038/aps.2013.26 23645011/?report=reader!4002892!23645011     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Acta+Pharmacol+Sin 2013 ; 34 (6): 725-31 Nephropedia Template TP {{tp|p=23645011|t=2013. Stem cells and small molecule screening: haploid embryonic stem cells as a new tool |pdf=|usr=}}{{23645011}} gab.com Text Stem cells and small molecule screening: haploid embryonic stem cells as a new tool JO: Acta Pharmacol Sin http://www.kidney.de/pget.php?&tw=1&pmid=23645011 #FOAvip Stem cells can both self-renew and differentiate into various cell types under certain conditions, which makes them a good model for development and disease studies. Recently, chemical approaches have been widely applied in stem cell biology by promoting stem cell self-renewal, proliferation, differentiation and somatic cell reprogramming using specific small molecules. Conversely, stem cells and their derivatives also provide an efficient and robust platform for small molecule and drug screening. Here, we review the current research and applications of small molecules that modulate stem cell self-renewal and differentiation and improve reprogramming, as well as the applications that use stem cells as a tool for small molecule screening. Moreover, we introduce the recent advance in haploid embryonic stem cells research. Haploid embryonic stem cells maintain haploidy and stable growth over extensive passages, possess the ability to differentiate into all three germ layers in vitro and in vivo, and contribute to the germlines of chimeras when injected into blastocysts. Androgenetic haploid stem cells can also be used in place of sperm to produce fertile progeny after intracytoplasmic injection into mature oocytes. Such characteristics demonstrate that haploid stem cells are a new approach for genetic studies at both the cellular and animal levels and that they are a valuable platform for future small molecule screening. Twit Text FOAVip Stem cells and small molecule screening: haploid embryonic stem cells as a new tool ????Acta Pharmacol Sin http://www.kidney.de/pget.php?&tw=1&pmid=23645011 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=23645011 #FOAvip English Wikipedia <ref>{{Cite pmid|23645011}}</ref> Stem cells and small molecule screening: haploid embryonic stem cells as a new tool #MMPMID23645011 Wu B; Li W; Wang L; Liu ZH; Zhao XY Acta Pharmacol Sin 2013[Jun]; 34 (6): 725-31 PMID23645011show ga Stem cells can both self-renew and differentiate into various cell types under certain conditions, which makes them a good model for development and disease studies. Recently, chemical approaches have been widely applied in stem cell biology by promoting stem cell self-renewal, proliferation, differentiation and somatic cell reprogramming using specific small molecules. Conversely, stem cells and their derivatives also provide an efficient and robust platform for small molecule and drug screening. Here, we review the current research and applications of small molecules that modulate stem cell self-renewal and differentiation and improve reprogramming, as well as the applications that use stem cells as a tool for small molecule screening. Moreover, we introduce the recent advance in haploid embryonic stem cells research. Haploid embryonic stem cells maintain haploidy and stable growth over extensive passages, possess the ability to differentiate into all three germ layers in vitro and in vivo, and contribute to the germlines of chimeras when injected into blastocysts. Androgenetic haploid stem cells can also be used in place of sperm to produce fertile progeny after intracytoplasmic injection into mature oocytes. Such characteristics demonstrate that haploid stem cells are a new approach for genetic studies at both the cellular and animal levels and that they are a valuable platform for future small molecule screening. |Animals[MESH] |Cell Differentiation/drug effects[MESH] |Cellular Reprogramming/drug effects[MESH] |Drug Design[MESH] |Embryonic Stem Cells/*drug effects/metabolism[MESH] |Haploidy[MESH] |High-Throughput Screening Assays/*methods[MESH] |Humans[MESH] |Small Molecule Libraries/chemistry/*pharmacology[MESH]Stem cells and small molecule screening: haploid embryonic stem cells (epmc).pdf DeepDyve Pubget Overpricing