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10.1002/wrna.1164 http://scihub22266oqcxt.onion/10.1002/wrna.1164 23606593!7169773!23606593     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Wiley+Interdiscip+Rev+RNA 2013 ; 4 (4): 351-67 Nephropedia Template TP {{tp|p=23606593|t=2013. RNA synthetic mechanisms employed by diverse families of RNA viruses |pdf=|usr=}}{{23606593}} gab.com Text RNA synthetic mechanisms employed by diverse families of RNA viruses JO: Wiley Interdiscip Rev RNA http://www.kidney.de/pget.php?&tw=1&pmid=23606593 #FOAvip RNA viruses are ubiquitous in nature, infecting every known organism on the planet. These viruses can also be notorious human pathogens with significant medical and economic burdens. Central to the lifecycle of an RNA virus is the synthesis of new RNA molecules, a process that is mediated by specialized virally encoded enzymes called RNA-dependent RNA polymerases (RdRps). RdRps directly catalyze phosphodiester bond formation between nucleoside triphosphates in an RNA-templated manner. These enzymes are strikingly conserved in their structural and functional features, even among diverse RNA viruses belonging to different families. During host cell infection, the activities of viral RdRps are often regulated by viral cofactor proteins. Cofactors can modulate the type and timing of RNA synthesis by directly engaging the RdRp and/or by indirectly affecting its capacity to recognize template RNA. High-resolution structures of RdRps as apoenzymes, bound to RNA templates, in the midst of catalysis, and/or interacting with regulatory cofactor proteins, have dramatically increased our understanding of viral RNA synthetic mechanisms. Combined with elegant biochemical studies, such structures are providing a scientific platform for the rational design of antiviral agents aimed at preventing and treating RNA virus-induced diseases. Twit Text FOAVip RNA synthetic mechanisms employed by diverse families of RNA viruses ????Wiley Interdiscip Rev RNA http://www.kidney.de/pget.php?&tw=1&pmid=23606593 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=23606593 #FOAvip English Wikipedia <ref>{{Cite pmid|23606593}}</ref> RNA synthetic mechanisms employed by diverse families of RNA viruses #MMPMID23606593 McDonald SM Wiley Interdiscip Rev RNA 2013[Jul]; 4 (4): 351-67 PMID23606593show ga RNA viruses are ubiquitous in nature, infecting every known organism on the planet. These viruses can also be notorious human pathogens with significant medical and economic burdens. Central to the lifecycle of an RNA virus is the synthesis of new RNA molecules, a process that is mediated by specialized virally encoded enzymes called RNA-dependent RNA polymerases (RdRps). RdRps directly catalyze phosphodiester bond formation between nucleoside triphosphates in an RNA-templated manner. These enzymes are strikingly conserved in their structural and functional features, even among diverse RNA viruses belonging to different families. During host cell infection, the activities of viral RdRps are often regulated by viral cofactor proteins. Cofactors can modulate the type and timing of RNA synthesis by directly engaging the RdRp and/or by indirectly affecting its capacity to recognize template RNA. High-resolution structures of RdRps as apoenzymes, bound to RNA templates, in the midst of catalysis, and/or interacting with regulatory cofactor proteins, have dramatically increased our understanding of viral RNA synthetic mechanisms. Combined with elegant biochemical studies, such structures are providing a scientific platform for the rational design of antiviral agents aimed at preventing and treating RNA virus-induced diseases. |Animals[MESH] |Coenzymes/metabolism[MESH] |Humans[MESH] |Models, Biological[MESH] |Models, Molecular[MESH] |Plants/virology[MESH] |Protein Conformation[MESH] |RNA Viruses/*enzymology[MESH] |RNA, Viral/*biosynthesis[MESH]RNA synthetic mechanisms employed by diverse families of RNA viruses (epmc).pdf DeepDyve Pubget Overpricing