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10.1038/srep01686 http://scihub22266oqcxt.onion/10.1038/srep01686 23594967!3629412!23594967     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sci+Rep 2013 ; 3 (ä): 1686 Nephropedia Template TP {{tp|p=23594967|t=2013. Inhibition of novel beta coronavirus replication by a combination of interferon-alpha2b and ribavirin |pdf=|usr=}}{{23594967}} gab.com Text Inhibition of novel beta coronavirus replication by a combination of interferon-alpha2b and ribavirin JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=23594967 #FOAvip The identification of a novel beta coronavirus, nCoV, as the causative agent of severe respiratory illness in humans originating in Saudi Arabia, Qatar and Jordan has raised concerns about the possibility of a coronavirus pandemic similar to that of SARS-CoV. As a definitive treatment regimen has never been thoroughly evaluated for coronavirus infections, there is an urgent need to rapidly identify potential therapeutics to address future cases of nCoV. To determine an intervention strategy, the effect of interferon-alpha2b and ribavirin on nCoV isolate hCoV-EMC/2012 replication in Vero and LLC-MK2 cells was evaluated. hCoV-EMC/2012 was sensitive to both interferon-alpha2b and ribavirin alone in Vero and LLC-MK2 cells, but only at relatively high concentrations; however, when combined, lower concentrations of interferon-alpha2b and ribavirin achieved comparable endpoints. Thus, a combination of interferon-alpha2b and ribavirin, which are already commonly used in the clinic, may be useful for patient management in the event of future nCoV infections. Twit Text FOAVip Inhibition of novel beta coronavirus replication by a combination of interferon-alpha2b and ribavirin ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=23594967 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=23594967 #FOAvip English Wikipedia <ref>{{Cite pmid|23594967}}</ref> Inhibition of novel beta coronavirus replication by a combination of interferon-alpha2b and ribavirin #MMPMID23594967 Falzarano D; de Wit E; Martellaro C; Callison J; Munster VJ; Feldmann H Sci Rep 2013[]; 3 (ä): 1686 PMID23594967show ga The identification of a novel beta coronavirus, nCoV, as the causative agent of severe respiratory illness in humans originating in Saudi Arabia, Qatar and Jordan has raised concerns about the possibility of a coronavirus pandemic similar to that of SARS-CoV. As a definitive treatment regimen has never been thoroughly evaluated for coronavirus infections, there is an urgent need to rapidly identify potential therapeutics to address future cases of nCoV. To determine an intervention strategy, the effect of interferon-alpha2b and ribavirin on nCoV isolate hCoV-EMC/2012 replication in Vero and LLC-MK2 cells was evaluated. hCoV-EMC/2012 was sensitive to both interferon-alpha2b and ribavirin alone in Vero and LLC-MK2 cells, but only at relatively high concentrations; however, when combined, lower concentrations of interferon-alpha2b and ribavirin achieved comparable endpoints. Thus, a combination of interferon-alpha2b and ribavirin, which are already commonly used in the clinic, may be useful for patient management in the event of future nCoV infections. |Animals[MESH] |Chlorocebus aethiops[MESH] |Coronavirus/*drug effects/*physiology[MESH] |Drug Combinations[MESH] |Interferon-alpha/*administration & dosage[MESH] |Ribavirin/*administration & dosage[MESH] |Vero Cells[MESH]Inhibition of novel beta coronavirus replication by a combination of i(epmc).pdf DeepDyve Pubget Overpricing