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http://scihub22266oqcxt.onion/10.3109/17453674.2013.792028
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  • Rising incidence of Enterococcus species in microbiological specimens from orthopedic patients correlates to increased use of cefuroxime: a study concentrating on tissue samples #MMPMID23594224
  • Siesing PC; Alva-Jorgensen JP; Brodersen J; Arpi M; Jensen PE
  • Acta Orthop 2013[Jun]; 84 (3): 319-22 PMID23594224garesp_yesshow ga
  • BACKGROUND AND PURPOSE: Enterococci are emerging causes of severe infections, including wound and bone infections in orthopedic patients. The main purpose of this study was to determine whether there was a correlation between the incidence of enterococci in tissue samples (biopsies) from orthopedic patients and consumption of cefuroxime in the orthopedic department. METHODS AND RESULTS: Data were obtained from the department of clinical microbiology and the hospital pharmacy. The consumption of cefuroxime successively increased from 40 defined daily doses (DDD)/10(3) bed days in 2002 to 212 DDD/10(3) bed days in 2009. The incidence of patients with enterococci in tissue samples increased steadily from 1.03/10(3) bed days in 2002 to 5.90/10(3) bed days in 2009. Regression analysis revealed a significant correlation between the consumption of cefuroxime and the incidence of enterococci. INTERPRETATION: Continuous surveillance of species distribution, resistance rates, and antibiotic consumption is of utmost importance for optimal antibiotic strategy in orthopedic patients.
  • |*Orthopedic Procedures[MESH]
  • |Anti-Bacterial Agents/*administration & dosage[MESH]
  • |Cefuroxime/*administration & dosage[MESH]
  • |Cross Infection/epidemiology/microbiology[MESH]
  • |Denmark/epidemiology[MESH]
  • |Drug Utilization/statistics & numerical data/trends[MESH]
  • |Enterococcus/classification/*isolation & purification[MESH]
  • |Gram-Positive Bacterial Infections/*epidemiology/microbiology[MESH]
  • |Humans[MESH]
  • |Incidence[MESH]
  • |Retrospective Studies[MESH]


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