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10.1111/aji.12118 http://scihub22266oqcxt.onion/10.1111/aji.12118 23590581!ä!23590581 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Am+J+Reprod+Immunol 2013 ; 70 (3): 213-20 Nephropedia Template TP {{tp|p=23590581|t=2013. Magnesium sulfate increases intracellular magnesium reducing inflammatory cytokine release in neonates |pdf=|usr=}}{{23590581}} gab.com Text Magnesium sulfate increases intracellular magnesium reducing inflammatory cytokine release in neonates JO: Am J Reprod Immunol http://www.kidney.de/pget.php?&tw=1&pmid=23590581 #FOAvip PROBLEM: Magnesium sulfate (MgSO4 ) exposure reduces the risk of cerebral palsy. As neonatal inflammatory cytokine levels strongly correlate with neurologic outcome, we hypothesize that MgSO4 decreases inflammatory cytokine production. METHOD OF STUDY: We assessed the effect of MgSO4 on cellular magnesium levels, cytokine production, and release within THP-1 and cord blood mononuclear cells. RESULTS: MgSO4 exposure increased intracellular magnesium levels, reducing the frequency of THP-1 cells producing IL-1beta, IL-8, and TNF-alpha following LPS stimulation. Significant reductions in the frequency of neonatal monocytes producing TNF-alpha (48%) and IL-6 (37%) were seen following LPS stimulation, and MgSO4 also significantly decreased the frequency of monocytes producing TNF-alpha (35%) under basal conditions. Decreased cytokine production was confirmed via ELISA, demonstrating a sustained effect and dose response. Magnesium also reduced cytokine production following stimulation with TLR ligands representing obstetrical infections (group B Streptococcus and Mycoplasma) and in preterm neonatal monocytes. CONCLUSION: MgSO4 increases intracellular magnesium, reducing inflammatory cytokine production and release, potentially elucidating the mechanism by which MgSO4 prevents cerebral palsy, eclampsia, and preterm birth. Twit Text FOAVip Magnesium sulfate increases intracellular magnesium reducing inflammatory cytokine release in neonates ????Am J Reprod Immunol http://www.kidney.de/pget.php?&tw=1&pmid=23590581 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=23590581 #FOAvip English Wikipedia <ref>{{Cite pmid|23590581}}</ref> Magnesium sulfate increases intracellular magnesium reducing inflammatory cytokine release in neonates #MMPMID23590581 Suzuki-Kakisaka H; Sugimoto J; Tetarbe M; Romani AM; Ramirez Kitchen CM; Bernstein HB Am J Reprod Immunol 2013[Sep]; 70 (3): 213-20 PMID23590581show ga PROBLEM: Magnesium sulfate (MgSO4 ) exposure reduces the risk of cerebral palsy. As neonatal inflammatory cytokine levels strongly correlate with neurologic outcome, we hypothesize that MgSO4 decreases inflammatory cytokine production. METHOD OF STUDY: We assessed the effect of MgSO4 on cellular magnesium levels, cytokine production, and release within THP-1 and cord blood mononuclear cells. RESULTS: MgSO4 exposure increased intracellular magnesium levels, reducing the frequency of THP-1 cells producing IL-1beta, IL-8, and TNF-alpha following LPS stimulation. Significant reductions in the frequency of neonatal monocytes producing TNF-alpha (48%) and IL-6 (37%) were seen following LPS stimulation, and MgSO4 also significantly decreased the frequency of monocytes producing TNF-alpha (35%) under basal conditions. Decreased cytokine production was confirmed via ELISA, demonstrating a sustained effect and dose response. Magnesium also reduced cytokine production following stimulation with TLR ligands representing obstetrical infections (group B Streptococcus and Mycoplasma) and in preterm neonatal monocytes. CONCLUSION: MgSO4 increases intracellular magnesium, reducing inflammatory cytokine production and release, potentially elucidating the mechanism by which MgSO4 prevents cerebral palsy, eclampsia, and preterm birth. |Cell Line[MESH] |Cells, Cultured[MESH] |Cytokines/*drug effects/metabolism[MESH] |Fetal Blood/cytology/immunology[MESH] |Humans[MESH] |Infant, Newborn[MESH] |Inflammation/*immunology[MESH] |Interleukin-6/immunology/pharmacology[MESH] |Leukocytes, Mononuclear/*drug effects/immunology/metabolism[MESH] |Magnesium Sulfate/*pharmacology[MESH] |Magnesium/*metabolism/pharmacology[MESH] |Monocytes/*drug effects/immunology/metabolism[MESH] |Premature Birth/immunology[MESH]Magnesium sulfate increases intracellular magnesium reducing inflammat(epmc).pdf DeepDyve Pubget Overpricing