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10.1152/physrev.00023.2012 http://scihub22266oqcxt.onion/10.1152/physrev.00023.2012 23589833!3768104!23589833     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Physiol+Rev 2013 ; 93 (2): 803-959 Nephropedia Template TP {{tp|p=23589833|t=2013. The divergence, actions, roles, and relatives of sodium-coupled bicarbonate transporters |pdf=|usr=}}{{23589833}} gab.com Text The divergence, actions, roles, and relatives of sodium-coupled bicarbonate transporters JO: Physiol Rev http://www.kidney.de/pget.php?&tw=1&pmid=23589833 #FOAvip The mammalian Slc4 (Solute carrier 4) family of transporters is a functionally diverse group of 10 multi-spanning membrane proteins that includes three Cl-HCO3 exchangers (AE1-3), five Na(+)-coupled HCO3(-) transporters (NCBTs), and two other unusual members (AE4, BTR1). In this review, we mainly focus on the five mammalian NCBTs-NBCe1, NBCe2, NBCn1, NDCBE, and NBCn2. Each plays a specialized role in maintaining intracellular pH and, by contributing to the movement of HCO3(-) across epithelia, in maintaining whole-body pH and otherwise contributing to epithelial transport. Disruptions involving NCBT genes are linked to blindness, deafness, proximal renal tubular acidosis, mental retardation, and epilepsy. We also review AE1-3, AE4, and BTR1, addressing their relevance to the study of NCBTs. This review draws together recent advances in our understanding of the phylogenetic origins and physiological relevance of NCBTs and their progenitors. Underlying these advances is progress in such diverse disciplines as physiology, molecular biology, genetics, immunocytochemistry, proteomics, and structural biology. This review highlights the key similarities and differences between individual NCBTs and the genes that encode them and also clarifies the sometimes confusing NCBT nomenclature. Twit Text FOAVip The divergence, actions, roles, and relatives of sodium-coupled bicarbonate transporters ????Physiol Rev http://www.kidney.de/pget.php?&tw=1&pmid=23589833 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=23589833 #FOAvip English Wikipedia <ref>{{Cite pmid|23589833}}</ref> The divergence, actions, roles, and relatives of sodium-coupled bicarbonate transporters #MMPMID23589833 Parker MD; Boron WF Physiol Rev 2013[Apr]; 93 (2): 803-959 PMID23589833show ga The mammalian Slc4 (Solute carrier 4) family of transporters is a functionally diverse group of 10 multi-spanning membrane proteins that includes three Cl-HCO3 exchangers (AE1-3), five Na(+)-coupled HCO3(-) transporters (NCBTs), and two other unusual members (AE4, BTR1). In this review, we mainly focus on the five mammalian NCBTs-NBCe1, NBCe2, NBCn1, NDCBE, and NBCn2. Each plays a specialized role in maintaining intracellular pH and, by contributing to the movement of HCO3(-) across epithelia, in maintaining whole-body pH and otherwise contributing to epithelial transport. Disruptions involving NCBT genes are linked to blindness, deafness, proximal renal tubular acidosis, mental retardation, and epilepsy. We also review AE1-3, AE4, and BTR1, addressing their relevance to the study of NCBTs. This review draws together recent advances in our understanding of the phylogenetic origins and physiological relevance of NCBTs and their progenitors. Underlying these advances is progress in such diverse disciplines as physiology, molecular biology, genetics, immunocytochemistry, proteomics, and structural biology. This review highlights the key similarities and differences between individual NCBTs and the genes that encode them and also clarifies the sometimes confusing NCBT nomenclature. |Acidosis, Renal Tubular/genetics/metabolism[MESH] |Animals[MESH] |Biological Evolution[MESH] |Chloride-Bicarbonate Antiporters/genetics/*metabolism[MESH] |Humans[MESH] |Molecular Sequence Data[MESH]The divergence, actions, roles, and relatives of sodium-coupled bicarb(epmc).pdf DeepDyve Pubget Overpricing