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10.5137/1019-5149.JTN.5582-11.1 http://scihub22266oqcxt.onion/10.5137/1019-5149.JTN.5582-11.1 23546895!ä!23546895 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\23546895.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Turk+Neurosurg 2013 ; 23 (2): 129-37 Nephropedia Template TP {{tp|p=23546895|t=2013. Combined treatment with progesterone and magnesium sulfate positively affects traumatic brain injury in immature rats |pdf=|usr=}}{{23546895}} gab.com Text Combined treatment with progesterone and magnesium sulfate positively affects traumatic brain injury in immature rats JO: Turk Neurosurg http://www.kidney.de/pget.php?&tw=1&pmid=23546895 #FOAvip AIM: It is well known that head trauma results in damage in hippocampal and cortical areas of the brain and impairs cognitive functions. The aim of this study is to explore the neuroprotective effect of combination therapy with magnesium sulphate (MgSO4) and progesterone in the 7-days-old rat pups subjected to contusion injury. MATERIAL AND METHODS: Progesterone (8 mg/kg) and MgSO4 (150 mg/kg) were injected intraperitoneally immediately after induction of traumatic brain injury. Half of groups were evaluated 24 hours later, the remaining animals 3 weeks after trauma or sham surgery. Anxiety levels were assessed with open field activity and elevated plus maze; learning and memory performance were evaluated with Morris Water maze in postnatal 27 days. RESULTS: Combined therapy with progesterone and magnesium sulfate significantly attenuated trauma-induced neuronal death, increased brain VEGF levels and improved spatial memory deficits that appear later in life. Brain VEGF levels were higher in rats that received combined therapy compared to rats that received either medication alone. Moreover, rats that received combined therapy had reduced hipocampus and prefrontal cortex apoptosis in the acute period. CONCLUSION: These results demonstrate that combination of drugs with different mechanisms of action may be preferred in the treatment of head trauma. Twit Text FOAVip Combined treatment with progesterone and magnesium sulfate positively affects traumatic brain injury in immature rats ????Turk Neurosurg http://www.kidney.de/pget.php?&tw=1&pmid=23546895 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=23546895 #FOAvip English Wikipedia <ref>{{Cite pmid|23546895}}</ref> Combined treatment with progesterone and magnesium sulfate positively affects traumatic brain injury in immature rats #MMPMID23546895 Uysal N; Baykara B; Kiray M; Cetin F; Aksu I; Dayi A; Gurpinar T; Ozdemir D; Arda MN Turk Neurosurg 2013[]; 23 (2): 129-37 PMID23546895show ga AIM: It is well known that head trauma results in damage in hippocampal and cortical areas of the brain and impairs cognitive functions. The aim of this study is to explore the neuroprotective effect of combination therapy with magnesium sulphate (MgSO4) and progesterone in the 7-days-old rat pups subjected to contusion injury. MATERIAL AND METHODS: Progesterone (8 mg/kg) and MgSO4 (150 mg/kg) were injected intraperitoneally immediately after induction of traumatic brain injury. Half of groups were evaluated 24 hours later, the remaining animals 3 weeks after trauma or sham surgery. Anxiety levels were assessed with open field activity and elevated plus maze; learning and memory performance were evaluated with Morris Water maze in postnatal 27 days. RESULTS: Combined therapy with progesterone and magnesium sulfate significantly attenuated trauma-induced neuronal death, increased brain VEGF levels and improved spatial memory deficits that appear later in life. Brain VEGF levels were higher in rats that received combined therapy compared to rats that received either medication alone. Moreover, rats that received combined therapy had reduced hipocampus and prefrontal cortex apoptosis in the acute period. CONCLUSION: These results demonstrate that combination of drugs with different mechanisms of action may be preferred in the treatment of head trauma. |*Neuroprotective Agents[MESH] |Animals[MESH] |Anxiety/etiology/psychology[MESH] |Apoptosis[MESH] |Brain Injuries/*drug therapy/pathology/psychology[MESH] |Brain/pathology[MESH] |DNA Fragmentation[MESH] |Magnesium Sulfate/*pharmacology[MESH] |Maze Learning/drug effects[MESH] |Memory/drug effects/physiology[MESH] |Progesterone/*pharmacology[MESH] |Rats[MESH]Combined treatment with progesterone and magnesium sulfate positively (epmc).pdf DeepDyve Pubget Overpricing