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10.1038/nm.3142 http://scihub22266oqcxt.onion/10.1038/nm.3142 23502960!ä!23502960 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Med 2013 ; 19 (4): 481-7 Nephropedia Template TP {{tp|p=23502960|t=2013. Focal segmental glomerulosclerosis is induced by microRNA-193a and its downregulation of WT1 |pdf=|usr=}}{{23502960}} gab.com Text Focal segmental glomerulosclerosis is induced by microRNA-193a and its downregulation of WT1 JO: Nat Med http://www.kidney.de/pget.php?&tw=1&pmid=23502960 #FOAvip Focal segmental glomerulosclerosis (FSGS) is a frequent and severe glomerular disease characterized by destabilization of podocyte foot processes. We report that transgenic expression of the microRNA miR-193a in mice rapidly induces FSGS with extensive podocyte foot process effacement. Mechanistically, miR-193a inhibits the expression of the Wilms' tumor protein (WT1), a transcription factor and master regulator of podocyte differentiation and homeostasis. Decreased expression levels of WT1 lead to downregulation of its target genes PODXL (podocalyxin) and NPHS1 (nephrin), as well as several other genes crucial for the architecture of podocytes, initiating a catastrophic collapse of the entire podocyte-stabilizing system. We found upregulation of miR-193a in isolated glomeruli from individuals with FSGS compared to normal kidneys or individuals with other glomerular diseases. Thus, upregulation of miR-193a provides a new pathogenic mechanism for FSGS and is a potential therapeutic target. Twit Text FOAVip Focal segmental glomerulosclerosis is induced by microRNA-193a and its downregulation of WT1 ????Nat Med http://www.kidney.de/pget.php?&tw=1&pmid=23502960 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=23502960 #FOAvip English Wikipedia <ref>{{Cite pmid|23502960}}</ref> Focal segmental glomerulosclerosis is induced by microRNA-193a and its downregulation of WT1 #MMPMID23502960 Gebeshuber CA; Kornauth C; Dong L; Sierig R; Seibler J; Reiss M; Tauber S; Bilban M; Wang S; Kain R; Bohmig GA; Moeller MJ; Grone HJ; Englert C; Martinez J; Kerjaschki D Nat Med 2013[Apr]; 19 (4): 481-7 PMID23502960show ga Focal segmental glomerulosclerosis (FSGS) is a frequent and severe glomerular disease characterized by destabilization of podocyte foot processes. We report that transgenic expression of the microRNA miR-193a in mice rapidly induces FSGS with extensive podocyte foot process effacement. Mechanistically, miR-193a inhibits the expression of the Wilms' tumor protein (WT1), a transcription factor and master regulator of podocyte differentiation and homeostasis. Decreased expression levels of WT1 lead to downregulation of its target genes PODXL (podocalyxin) and NPHS1 (nephrin), as well as several other genes crucial for the architecture of podocytes, initiating a catastrophic collapse of the entire podocyte-stabilizing system. We found upregulation of miR-193a in isolated glomeruli from individuals with FSGS compared to normal kidneys or individuals with other glomerular diseases. Thus, upregulation of miR-193a provides a new pathogenic mechanism for FSGS and is a potential therapeutic target. |Animals[MESH] |Down-Regulation/physiology[MESH] |Doxycycline/pharmacology[MESH] |Glomerulosclerosis, Focal Segmental/*etiology/genetics/pathology[MESH] |Humans[MESH] |Kidney/pathology[MESH] |Male[MESH] |Mice[MESH] |Mice, Knockout[MESH] |Mice, Transgenic[MESH] |MicroRNAs/*physiology[MESH] |Podocytes/metabolism[MESH]Focal segmental glomerulosclerosis is induced by microRNA-193a and its(epmc).pdf DeepDyve Pubget Overpricing