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10.1186/1741-7015-11-64

http://scihub22266oqcxt.onion/10.1186/1741-7015-11-64
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suck abstract from ncbi


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pmid23497361      BMC+Med 2013 ; 11 (ä): 64
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  • A narrative review on the similarities and dissimilarities between myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and sickness behavior #MMPMID23497361
  • Morris G; Anderson G; Galecki P; Berk M; Maes M
  • BMC Med 2013[Mar]; 11 (ä): 64 PMID23497361show ga
  • It is of importance whether myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a variant of sickness behavior. The latter is induced by acute infections/injury being principally mediated through proinflammatory cytokines. Sickness is a beneficial behavioral response that serves to enhance recovery, conserves energy and plays a role in the resolution of inflammation. There are behavioral/symptomatic similarities (for example, fatigue, malaise, hyperalgesia) and dissimilarities (gastrointestinal symptoms, anorexia and weight loss) between sickness and ME/CFS. While sickness is an adaptive response induced by proinflammatory cytokines, ME/CFS is a chronic, disabling disorder, where the pathophysiology is related to activation of immunoinflammatory and oxidative pathways and autoimmune responses. While sickness behavior is a state of energy conservation, which plays a role in combating pathogens, ME/CFS is a chronic disease underpinned by a state of energy depletion. While sickness is an acute response to infection/injury, the trigger factors in ME/CFS are less well defined and encompass acute and chronic infections, as well as inflammatory or autoimmune diseases. It is concluded that sickness behavior and ME/CFS are two different conditions.
  • |*Illness Behavior/physiology[MESH]
  • |Animals[MESH]
  • |Autoimmune Diseases/epidemiology/physiopathology/psychology[MESH]
  • |Depression/diagnosis/epidemiology/psychology[MESH]
  • |Fatigue Syndrome, Chronic/*epidemiology/physiopathology/psychology[MESH]
  • |Fatigue/epidemiology/physiopathology/psychology[MESH]


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