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10.1021/cb400102t http://scihub22266oqcxt.onion/10.1021/cb400102t 23474169/?report=reader!3657337!23474169     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       ACS+Chem+Biol 2013 ; 8 (5): 908-13 Nephropedia Template TP {{tp|p=23474169|t=2013. Discovery of the antibiotic phosacetamycin via a new mass spectrometry-based method for phosphonic acid detection |pdf=|usr=}}{{23474169}} gab.com Text Discovery of the antibiotic phosacetamycin via a new mass spectrometry-based method for phosphonic acid detection JO: ACS Chem Biol http://www.kidney.de/pget.php?&tw=1&pmid=23474169 #FOAvip Naturally occurring phosphonates such as phosphinothricin (Glufosinate, a commercially used herbicide) and fosfomycin (Monurol, a clinically used antibiotic) have proved to be potent and useful biocides. Yet this class of natural products is still an under explored family of secondary metabolites. Discovery of the biosynthetic pathways responsible for the production of these compounds has been simplified by using gene based screening approaches, but detection and identification of the natural products the genes produce have been hampered by a lack of high-throughput methods for screening potential producers under various culture conditions. Here, we present an efficient mass-spectrometric method for the selective detection of natural products containing phosphonate and phosphinate functional groups. We have used this method to identify a new phosphonate metabolite, phosacetamycin, whose structure, biological activity, and biosynthetic gene cluster are reported. Twit Text FOAVip Discovery of the antibiotic phosacetamycin via a new mass spectrometry-based method for phosphonic acid detection ????ACS Chem Biol http://www.kidney.de/pget.php?&tw=1&pmid=23474169 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=23474169 #FOAvip English Wikipedia <ref>{{Cite pmid|23474169}}</ref> Discovery of the antibiotic phosacetamycin via a new mass spectrometry-based method for phosphonic acid detection #MMPMID23474169 Evans BS; Zhao C; Gao J; Evans CM; Ju KS; Doroghazi JR; van der Donk WA; Kelleher NL; Metcalf WW ACS Chem Biol 2013[May]; 8 (5): 908-13 PMID23474169show ga Naturally occurring phosphonates such as phosphinothricin (Glufosinate, a commercially used herbicide) and fosfomycin (Monurol, a clinically used antibiotic) have proved to be potent and useful biocides. Yet this class of natural products is still an under explored family of secondary metabolites. Discovery of the biosynthetic pathways responsible for the production of these compounds has been simplified by using gene based screening approaches, but detection and identification of the natural products the genes produce have been hampered by a lack of high-throughput methods for screening potential producers under various culture conditions. Here, we present an efficient mass-spectrometric method for the selective detection of natural products containing phosphonate and phosphinate functional groups. We have used this method to identify a new phosphonate metabolite, phosacetamycin, whose structure, biological activity, and biosynthetic gene cluster are reported. |Acetamides/*analysis/chemistry/*pharmacology[MESH] |Anti-Bacterial Agents/analysis/*chemistry/*pharmacology[MESH] |Biosynthetic Pathways/genetics[MESH] |Chromatography, Affinity/methods[MESH] |Drug Evaluation, Preclinical/*methods[MESH] |Escherichia coli/drug effects[MESH] |Genome, Bacterial[MESH] |Magnetic Resonance Spectroscopy[MESH] |Mass Spectrometry/*methods[MESH] |Microbial Sensitivity Tests[MESH] |Molecular Sequence Data[MESH] |Molecular Structure[MESH] |Multigene Family[MESH] |Phosphates/isolation & purification[MESH] |Phosphorous Acids/*analysis/chemistry/*pharmacology[MESH]Discovery of the antibiotic phosacetamycin via a new mass spectrometry(epmc).pdf DeepDyve Pubget Overpricing