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  • Discovery of the antibiotic phosacetamycin via a new mass spectrometry-based method for phosphonic acid detection #MMPMID23474169
  • Evans BS; Zhao C; Gao J; Evans CM; Ju KS; Doroghazi JR; van der Donk WA; Kelleher NL; Metcalf WW
  • ACS Chem Biol 2013[May]; 8 (5): 908-13 PMID23474169garesp_yesshow ga
  • Naturally occurring phosphonates such as phosphinothricin (Glufosinate, a commercially used herbicide) and fosfomycin (Monurol, a clinically used antibiotic) have proved to be potent and useful biocides. Yet this class of natural products is still an under explored family of secondary metabolites. Discovery of the biosynthetic pathways responsible for the production of these compounds has been simplified by using gene based screening approaches, but detection and identification of the natural products the genes produce have been hampered by a lack of high-throughput methods for screening potential producers under various culture conditions. Here, we present an efficient mass-spectrometric method for the selective detection of natural products containing phosphonate and phosphinate functional groups. We have used this method to identify a new phosphonate metabolite, phosacetamycin, whose structure, biological activity, and biosynthetic gene cluster are reported.
  • |Acetamides/*analysis/chemistry/*pharmacology[MESH]
  • |Anti-Bacterial Agents/analysis/*chemistry/*pharmacology[MESH]
  • |Biosynthetic Pathways/genetics[MESH]
  • |Chromatography, Affinity/methods[MESH]
  • |Drug Evaluation, Preclinical/*methods[MESH]
  • |Escherichia coli/drug effects[MESH]
  • |Genome, Bacterial[MESH]
  • |Magnetic Resonance Spectroscopy[MESH]
  • |Mass Spectrometry/*methods[MESH]
  • |Microbial Sensitivity Tests[MESH]
  • |Molecular Sequence Data[MESH]
  • |Molecular Structure[MESH]
  • |Multigene Family[MESH]
  • |Phosphates/isolation & purification[MESH]
  • |Phosphorous Acids/*analysis/chemistry/*pharmacology[MESH]
  • |Streptomyces/*genetics/metabolism[MESH]

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    908 5.8 2013