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10.1152/ajprenal.00287.2012 http://scihub22266oqcxt.onion/10.1152/ajprenal.00287.2012 23467423!3651624!23467423     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Am+J+Physiol+Renal+Physiol 2013 ; 304 (10): F1274-82 Nephropedia Template TP {{tp|p=23467423|t=2013. miR-29c is downregulated in renal interstitial fibrosis in humans and rats and restored by HIF-alpha activation |pdf=|usr=}}{{23467423}} gab.com Text miR-29c is downregulated in renal interstitial fibrosis in humans and rats and restored by HIF-alpha activation JO: Am J Physiol Renal Physiol http://www.kidney.de/pget.php?&tw=1&pmid=23467423 #FOAvip Treatment with L-mimosine, which activates hypoxia-inducible factor-alpha (HIF-alpha), attenuates renal tubulointerstitial injury and improves renal function in a rat remnant kidney model. The miR-29 family of microRNAs directly targets a large number of extracellular matrix genes and reduces renal interstitial fibrosis. We analyzed microRNA expression profiles in rat remnant kidneys with or without treatment with L-mimosine. The expression of miR-29c was downregulated in rat remnant kidneys compared with sham control and significantly restored by the L-mimosine treatment. In cultured human kidney epithelial HK2 cells, cobalt chloride activated HIF-alpha and upregulated miR-29c expression. The upregulation of miR-29c expression was significantly attenuated by knockdown of HIF-1alpha or HIF-2alpha. Downregulation of miR-29c was associated with significant increases in interstitial fibrosis, collagen type II alpha1 (COL2A1) protein, and tropomyosin 1alpha (TPM1) protein in rat remnant kidneys and in kidneys from IgA nephropathy patients. The increases in rat remnant kidneys were attenuated by the L-mimosine treatment. COL2A1 and TPM1 were confirmed to be new, direct targets of miR-29c. In conclusion, miR-29c, an antifibrotic microRNA, is upregulated by HIF-alpha activation. MiR-29c is downregulated in renal interstitial fibrosis in humans and rats and restored by activation of HIF-alpha that attenuates fibrosis. Twit Text FOAVip miR-29c is downregulated in renal interstitial fibrosis in humans and rats and restored by HIF-alpha activation ????Am J Physiol Renal Physiol http://www.kidney.de/pget.php?&tw=1&pmid=23467423 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=23467423 #FOAvip English Wikipedia <ref>{{Cite pmid|23467423}}</ref> miR-29c is downregulated in renal interstitial fibrosis in humans and rats and restored by HIF-alpha activation #MMPMID23467423 Fang Y; Yu X; Liu Y; Kriegel AJ; Heng Y; Xu X; Liang M; Ding X Am J Physiol Renal Physiol 2013[May]; 304 (10): F1274-82 PMID23467423show ga Treatment with L-mimosine, which activates hypoxia-inducible factor-alpha (HIF-alpha), attenuates renal tubulointerstitial injury and improves renal function in a rat remnant kidney model. The miR-29 family of microRNAs directly targets a large number of extracellular matrix genes and reduces renal interstitial fibrosis. We analyzed microRNA expression profiles in rat remnant kidneys with or without treatment with L-mimosine. The expression of miR-29c was downregulated in rat remnant kidneys compared with sham control and significantly restored by the L-mimosine treatment. In cultured human kidney epithelial HK2 cells, cobalt chloride activated HIF-alpha and upregulated miR-29c expression. The upregulation of miR-29c expression was significantly attenuated by knockdown of HIF-1alpha or HIF-2alpha. Downregulation of miR-29c was associated with significant increases in interstitial fibrosis, collagen type II alpha1 (COL2A1) protein, and tropomyosin 1alpha (TPM1) protein in rat remnant kidneys and in kidneys from IgA nephropathy patients. The increases in rat remnant kidneys were attenuated by the L-mimosine treatment. COL2A1 and TPM1 were confirmed to be new, direct targets of miR-29c. In conclusion, miR-29c, an antifibrotic microRNA, is upregulated by HIF-alpha activation. MiR-29c is downregulated in renal interstitial fibrosis in humans and rats and restored by activation of HIF-alpha that attenuates fibrosis. |*Down-Regulation[MESH] |Animals[MESH] |Cell Line[MESH] |Fibrosis/genetics/metabolism[MESH] |Humans[MESH] |Hypoxia-Inducible Factor 1, alpha Subunit/*genetics/metabolism[MESH] |Kidney Diseases/*genetics/metabolism[MESH] |Kidney/drug effects/*metabolism[MESH] |Male[MESH] |MicroRNAs/*genetics/metabolism[MESH] |Mimosine/*pharmacology[MESH] |Mutagenesis, Site-Directed[MESH] |Rats[MESH]miR-29c is downregulated in renal interstitial fibrosis in humans and (epmc).pdf DeepDyve Pubget Overpricing