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10.1111/irv.12101

http://scihub22266oqcxt.onion/10.1111/irv.12101
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23462106!4634278!23462106
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suck abstract from ncbi


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pmid23462106      Influenza+Other+Respir+Viruses 2013 ; 7 (6): 1040-7
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  • Epidemiological and clinical features of human coronavirus infections among different subsets of patients #MMPMID23462106
  • Cabeca TK; Granato C; Bellei N
  • Influenza Other Respir Viruses 2013[Nov]; 7 (6): 1040-7 PMID23462106show ga
  • BACKGROUND: Epidemiological and clinical data of human coronaviruses (HCoVs) infections are restricted to span 1-3 years at most. We conducted a comprehensive 9-year study on HCoVs by analyzing 1137 respiratory samples from four subsets of patients (asymptomatic, general community, with comorbidities, and hospitalized) in Sao Paulo, Brazil. METHODS: A pan-coronavirus RT-PCR screening assay was performed, followed by species-specific real-time RT-PCR monoplex assays. RESULTS: Human coronaviruses were detected in 88 of 1137 (7.7%) of the samples. The most frequently detected HCoV species were NL63 (50.0%) and OC43 (27.3%). Patients with comorbidities presented the highest risk of acquiring coronavirus infection (odds ratio=4.17; 95% confidence interval=1.9-9.3), and children with heart diseases revealed a significant HCoV infection presence. Dyspnea was more associated with HCoV-229E infections (66.6%), and cyanosis was reported only in HCoV-OC43 infections. There were interseasonal differences in the detection frequencies, with HCoV-229E being predominant in the year 2004 (61.5%) and HCoV-NL63 (70.8%) in 2008. CONCLUSIONS: Our data provide a novel insight into the epidemiology and clinical knowledge of HCoVs among different subsets of patients, revealing that these viruses may cause more than mild respiratory tract disease.
  • |Adolescent[MESH]
  • |Adult[MESH]
  • |Aged[MESH]
  • |Animals[MESH]
  • |Brazil/epidemiology[MESH]
  • |Child[MESH]
  • |Child, Preschool[MESH]
  • |Coronavirus Infections/*epidemiology/*pathology[MESH]
  • |Coronavirus/*classification/genetics/*isolation & purification[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Infant[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |RNA, Viral/genetics[MESH]
  • |Real-Time Polymerase Chain Reaction[MESH]
  • |Reverse Transcriptase Polymerase Chain Reaction[MESH]


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