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10.1179/1743132813Y.0000000169 http://scihub22266oqcxt.onion/10.1179/1743132813Y.0000000169 23452578!ä!23452578       Neurol+Res 2013 ; 35 (2): 159-62 Nephropedia Template TP {{tp|p=23452578|t=2013. QTc prolongation after brain surgery |pdf=|usr=}}{{23452578}} gab.com Text QTc prolongation after brain surgery JO: Neurol Res http://www.kidney.de/pget.php?&tw=1&pmid=23452578 #FOAvip OBJECTIVE: Abnormalities observed in the electrocardiogram (ECG) after acute central nervous system (CNS) events have been reported. Our objective was to assess the incidence of heart rate-corrected QT interval (QTc) prolongation in patients admitted to the intensive care unit (ICU) after brain surgery. METHODS: Admission standard 12-lead ECGs were analyzed blinded to patient data. The QT interval was measured and Bazzett's formula was used to obtain QTc. Prolonged QTc was defined as >==450 ms. RESULTS: We included 114 patients in the study. The mean age was 49+/-17 years. Brain neoplasm was the surgical indication in 90% of the patients. The mean QTc was 470+/-42 ms. Prolonged QTc was found in 71% patients. The heart rate-corrected QT interval was between 450 ms and 500 ms in 52% and >500 ms in 19% of the patients. The heart rate and concentration of serum glucose were higher in the prolonged QTc group. Only 7.5% of all patients had hypokalemia (</=3 mEq/l). In the prolonged QTc group 9.2% had hypokalemia compared to 3.2% in normal QTc patients (P = 0.406). There were no significant associations between categories of QTc and the serum levels of creatinine, magnesium, calcium, sodium, or pH. Phenytoin and metoclopramide were not frequently used in patients with prolonged QTc. DISCUSSION: This study supports our hypothesis that prolonged QTc is frequently observed after a brain surgery. Hypokalemia, hypocalcaemia, and drugs such as metoclopramide or phenytoin could not explain the high incidence of prolonged QTc. Brain injury during a surgical procedure may be one of the primary causes of QTc prolongation after neurosurgery. Twit Text FOAVip QTc prolongation after brain surgery ????Neurol Res http://www.kidney.de/pget.php?&tw=1&pmid=23452578 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=23452578 #FOAvip English Wikipedia <ref>{{Cite pmid|23452578}}</ref> QTc prolongation after brain surgery #MMPMID23452578 Capparelli FJ; Abello M; Patricio Maskin L; Arista E; Hlavnicka A; Diaz MF; Varela D; Wainsztein NA Neurol Res 2013[Mar]; 35 (2): 159-62 PMID23452578show ga OBJECTIVE: Abnormalities observed in the electrocardiogram (ECG) after acute central nervous system (CNS) events have been reported. Our objective was to assess the incidence of heart rate-corrected QT interval (QTc) prolongation in patients admitted to the intensive care unit (ICU) after brain surgery. METHODS: Admission standard 12-lead ECGs were analyzed blinded to patient data. The QT interval was measured and Bazzett's formula was used to obtain QTc. Prolonged QTc was defined as >==450 ms. RESULTS: We included 114 patients in the study. The mean age was 49+/-17 years. Brain neoplasm was the surgical indication in 90% of the patients. The mean QTc was 470+/-42 ms. Prolonged QTc was found in 71% patients. The heart rate-corrected QT interval was between 450 ms and 500 ms in 52% and >500 ms in 19% of the patients. The heart rate and concentration of serum glucose were higher in the prolonged QTc group. Only 7.5% of all patients had hypokalemia ( |Anticonvulsants/adverse effects[MESH] |Antiemetics/adverse effects[MESH] |Argentina/epidemiology[MESH] |Blood Glucose/metabolism[MESH] |Brain/metabolism/*surgery[MESH] |Calcium/blood[MESH] |Creatinine/blood[MESH] |Female[MESH] |Humans[MESH] |Hydrogen-Ion Concentration[MESH] |Hypokalemia/epidemiology[MESH] |Incidence[MESH] |Long QT Syndrome/*epidemiology[MESH] |Magnesium/blood[MESH] |Male[MESH] |Metoclopramide/adverse effects[MESH] |Middle Aged[MESH] |Phenytoin/adverse effects[MESH] |Postoperative Complications/*epidemiology[MESH]QTc prolongation after brain surgery (epmc).pdf DeepDyve Pubget Overpricing