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10.1074/jbc.M112.446393 http://scihub22266oqcxt.onion/10.1074/jbc.M112.446393 23430254!3617255!23430254     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Biol+Chem 2013 ; 288 (14): 10124-10131 Nephropedia Template TP {{tp|p=23430254|t=2013. Renal proteinase-activated receptor 2, a new actor in the control of blood pressure and plasma potassium level |pdf=|usr=}}{{23430254}} gab.com Text Renal proteinase-activated receptor 2, a new actor in the control of blood pressure and plasma potassium level JO: J Biol Chem http://www.kidney.de/pget.php?&tw=1&pmid=23430254 #FOAvip Proteinase-activated receptor 2 (PAR2) is a G protein-coupled membrane receptor that is activated upon cleavage of its extracellular N-terminal domain by trypsin and related proteases. PAR2 is expressed in kidney collecting ducts, a main site of control of Na(+) and K(+) homeostasis, but its function remains unknown. We evaluated whether and how PAR2 might control electrolyte transport in collecting ducts, and thereby participate in the regulation of blood pressure and plasma K(+) concentration. PAR2 is expressed at the basolateral border of principal and intercalated cells of the collecting duct where it inhibits K(+) secretion and stimulates Na(+) reabsorption, respectively. Invalidation of PAR2 gene impairs the ability of the kidney to control Na(+) and K(+) balance and promotes hypotension and hypokalemia in response to Na(+) and K(+) depletion, respectively. This study not only reveals a new role of proteases in the control of blood pressure and plasma potassium level, but it also identifies a second membrane receptor, after angiotensin 2 receptor, that differentially controls sodium reabsorption and potassium secretion in the late distal tubule. Conversely to angiotensin 2 receptor, PAR2 is involved in the regulation of sodium and potassium balance in the context of either stimulation or nonstimulation of the renin/angiotensin/aldosterone system. Therefore PAR2 appears not only as a new actor of the aldosterone paradox, but also as an aldosterone-independent modulator of blood pressure and plasma potassium. Twit Text FOAVip Renal proteinase-activated receptor 2, a new actor in the control of blood pressure and plasma potassium level ????J Biol Chem http://www.kidney.de/pget.php?&tw=1&pmid=23430254 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=23430254 #FOAvip English Wikipedia <ref>{{Cite pmid|23430254}}</ref> Renal proteinase-activated receptor 2, a new actor in the control of blood pressure and plasma potassium level #MMPMID23430254 Morla L; Brideau G; Fila M; Crambert G; Cheval L; Houillier P; Ramakrishnan S; Imbert-Teboul M; Doucet A J Biol Chem 2013[Apr]; 288 (14): 10124-10131 PMID23430254show ga Proteinase-activated receptor 2 (PAR2) is a G protein-coupled membrane receptor that is activated upon cleavage of its extracellular N-terminal domain by trypsin and related proteases. PAR2 is expressed in kidney collecting ducts, a main site of control of Na(+) and K(+) homeostasis, but its function remains unknown. We evaluated whether and how PAR2 might control electrolyte transport in collecting ducts, and thereby participate in the regulation of blood pressure and plasma K(+) concentration. PAR2 is expressed at the basolateral border of principal and intercalated cells of the collecting duct where it inhibits K(+) secretion and stimulates Na(+) reabsorption, respectively. Invalidation of PAR2 gene impairs the ability of the kidney to control Na(+) and K(+) balance and promotes hypotension and hypokalemia in response to Na(+) and K(+) depletion, respectively. This study not only reveals a new role of proteases in the control of blood pressure and plasma potassium level, but it also identifies a second membrane receptor, after angiotensin 2 receptor, that differentially controls sodium reabsorption and potassium secretion in the late distal tubule. Conversely to angiotensin 2 receptor, PAR2 is involved in the regulation of sodium and potassium balance in the context of either stimulation or nonstimulation of the renin/angiotensin/aldosterone system. Therefore PAR2 appears not only as a new actor of the aldosterone paradox, but also as an aldosterone-independent modulator of blood pressure and plasma potassium. |*Gene Expression Regulation[MESH] |Aldosterone/metabolism[MESH] |Animals[MESH] |Blood Pressure[MESH] |Calcium/metabolism[MESH] |Diuretics/pharmacology[MESH] |Homeostasis[MESH] |Kidney/*metabolism[MESH] |Male[MESH] |Mice[MESH] |Mice, Transgenic[MESH] |Perfusion[MESH] |Potassium/*blood[MESH] |Rats[MESH] |Rats, Sprague-Dawley[MESH] |Receptor, PAR-2/*metabolism[MESH]Renal proteinase-activated receptor 2, a new actor in the control of b(epmc).pdf DeepDyve Pubget Overpricing