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10.1016/j.ajpath.2012.12.022 http://scihub22266oqcxt.onion/10.1016/j.ajpath.2012.12.022 23395090!ä!23395090 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Am+J+Pathol 2013 ; 182 (4): 1308-21 Nephropedia Template TP {{tp|p=23395090|t=2013. Early regulation of viral infection reduces inflammation and rescues mx-positive mice from lethal avian influenza infection |pdf=|usr=}}{{23395090}} gab.com Text Early regulation of viral infection reduces inflammation and rescues mx-positive mice from lethal avian influenza infection JO: Am J Pathol http://www.kidney.de/pget.php?&tw=1&pmid=23395090 #FOAvip Differing sensitivity of influenza A viruses to antiviral effects of the Myxovirus resistance (Mx) protein implies varying global gene expression profiles in the host. The role of Mx protein during lethal avian influenza (AI) virus infection was examined using Mx1-deficient C57BL/6 (B6-Mx1(-/-)) and congenic Mx1-expressing (B6-Mx1(+/+)) mice infected with a virulent, mouse-adapted avian H5N2 Ab/Korea/ma81/07 (Av/ma81) virus. After infection, B6-Mx1(+/+) mice were completely protected from lethal AI-induced mortality, and exhibited attenuated clinical disease and reduced viral titers and pathology in the lungs, compared with B6-Mx1(-/-) mice. Transcriptional profiling of lung tissues revealed that most of the genes up-regulated after infection are involved in activation of the immune response and host defense. Notably, more abundant and sustained expression of cytokine/chemokine genes was observed up to 3 dpi in B6-Mx1(-/-) mice, and this was associated with excessive induction of cytokines and chemokines. Consequently, massive infiltration of macrophages/monocytes and granulocytes into lung resulted in severe viral pneumonia and potentially contributed to decreased survival of B6-Mx1(-/-) mice. Taken together, our data show that dysregulated gene transcriptional activity corresponded to persistent induction of cytokine/chemokines and recruitment of cytokine-producing cells that promote inflammation in B6-Mx1(-/-) mouse lungs. Thus, we provide additional evidence of the interplay of genetic, molecular, and cellular correlates governed by the Mx1 protein that critically determine disease outcome during lethal AI virus infection. Twit Text FOAVip Early regulation of viral infection reduces inflammation and rescues mx-positive mice from lethal avian influenza infection ????Am J Pathol http://www.kidney.de/pget.php?&tw=1&pmid=23395090 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=23395090 #FOAvip English Wikipedia <ref>{{Cite pmid|23395090}}</ref> Early regulation of viral infection reduces inflammation and rescues mx-positive mice from lethal avian influenza infection #MMPMID23395090 Song MS; Cho YH; Park SJ; Pascua PN; Baek YH; Kwon HI; Lee OJ; Kong BW; Kim H; Shin EC; Kim CJ; Choi YK Am J Pathol 2013[Apr]; 182 (4): 1308-21 PMID23395090show ga Differing sensitivity of influenza A viruses to antiviral effects of the Myxovirus resistance (Mx) protein implies varying global gene expression profiles in the host. The role of Mx protein during lethal avian influenza (AI) virus infection was examined using Mx1-deficient C57BL/6 (B6-Mx1(-/-)) and congenic Mx1-expressing (B6-Mx1(+/+)) mice infected with a virulent, mouse-adapted avian H5N2 Ab/Korea/ma81/07 (Av/ma81) virus. After infection, B6-Mx1(+/+) mice were completely protected from lethal AI-induced mortality, and exhibited attenuated clinical disease and reduced viral titers and pathology in the lungs, compared with B6-Mx1(-/-) mice. Transcriptional profiling of lung tissues revealed that most of the genes up-regulated after infection are involved in activation of the immune response and host defense. Notably, more abundant and sustained expression of cytokine/chemokine genes was observed up to 3 dpi in B6-Mx1(-/-) mice, and this was associated with excessive induction of cytokines and chemokines. Consequently, massive infiltration of macrophages/monocytes and granulocytes into lung resulted in severe viral pneumonia and potentially contributed to decreased survival of B6-Mx1(-/-) mice. Taken together, our data show that dysregulated gene transcriptional activity corresponded to persistent induction of cytokine/chemokines and recruitment of cytokine-producing cells that promote inflammation in B6-Mx1(-/-) mouse lungs. Thus, we provide additional evidence of the interplay of genetic, molecular, and cellular correlates governed by the Mx1 protein that critically determine disease outcome during lethal AI virus infection. |Animals[MESH] |Bronchoalveolar Lavage Fluid[MESH] |Chickens[MESH] |Cytokines/pharmacology[MESH] |Dogs[MESH] |GTP-Binding Proteins/deficiency/*metabolism[MESH] |Gene Expression Profiling[MESH] |Gene Expression Regulation/drug effects[MESH] |Inflammation/complications/*pathology/virology[MESH] |Influenza A Virus, H5N2 Subtype/drug effects/pathogenicity[MESH] |Influenza in Birds/pathology/*prevention & control/*virology[MESH] |Interferons/pharmacology[MESH] |Interleukins/metabolism[MESH] |Lung/drug effects/immunology/pathology/virology[MESH] |Macrophages/drug effects/metabolism/pathology[MESH] |Mice[MESH] |Mice, Inbred C57BL[MESH] |Myxovirus Resistance Proteins[MESH] |Neutrophils/drug effects/metabolism/pathology[MESH] |Orthomyxoviridae Infections/genetics/*pathology/*virology[MESH]Early regulation of viral infection reduces inflammation and rescues m(epmc).pdf DeepDyve Pubget Overpricing