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10.3109/08820139009042023 http://scihub22266oqcxt.onion/10.3109/08820139009042023 2338360!ä!2338360 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Immunol+Invest 1990 ; 19 (1): 27-40 Nephropedia Template TP {{tp|p=2338360|t=1990. Modulation of lung-associated natural killer activity by resident and activated alveolar macrophages |pdf=|usr=}}{{2338360}} gab.com Text Modulation of lung-associated natural killer activity by resident and activated alveolar macrophages JO: Immunol Invest http://www.kidney.de/pget.php?&tw=1&pmid=2338360 #FOAvip Alveolar macrophages (AM) freshly obtained by bronchoalveolar lavage suppressed significantly, in a dose-dependent fashion, lung interstitial lymphocytes cytotoxicity against the NK-sensitive target cells, YAC-1. Kinetic experiments revealed that AM-mediated suppression of NK activity was seen following short-term incubation of AM with lymphocytes (4 h) and was unchanged after a 24 h co-culture period. Freshly obtained lung lymphocytes and lymphocytes incubated for 24 h were similarly inhibited by AM. In addition, incubation of AM for 24 h did not abrogate their suppressive effect on lung NK activity. Interestingly, AM-conditioned media, also caused a significant inhibition of lung NK activity. Furthermore, in vitro activation of AM with lipopolysaccharide (LPS, 5 micrograms/ml) and muramyl dipeptide (MDP, 20 micrograms/ml) significantly enhanced the inhibitory effect of AM on lung NK activity. Similarly, in vivo activation of AM locally by intratracheal instillation of attapulgite, an inflammatory agent, resulted in greater AM-mediated down regulation. Taken together, these data indicate that lung NK activity is modulated by locally derived factors and suggest that pharmacologic manipulation of AM may play a determining role in the activation of lung NK activity by biological response modifiers (BRM). Twit Text FOAVip Modulation of lung-associated natural killer activity by resident and activated alveolar macrophages ????Immunol Invest http://www.kidney.de/pget.php?&tw=1&pmid=2338360 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=2338360 #FOAvip English Wikipedia <ref>{{Cite pmid|2338360}}</ref> Modulation of lung-associated natural killer activity by resident and activated alveolar macrophages #MMPMID2338360 Lemaire I; St-Jean M Immunol Invest 1990[Feb]; 19 (1): 27-40 PMID2338360show ga Alveolar macrophages (AM) freshly obtained by bronchoalveolar lavage suppressed significantly, in a dose-dependent fashion, lung interstitial lymphocytes cytotoxicity against the NK-sensitive target cells, YAC-1. Kinetic experiments revealed that AM-mediated suppression of NK activity was seen following short-term incubation of AM with lymphocytes (4 h) and was unchanged after a 24 h co-culture period. Freshly obtained lung lymphocytes and lymphocytes incubated for 24 h were similarly inhibited by AM. In addition, incubation of AM for 24 h did not abrogate their suppressive effect on lung NK activity. Interestingly, AM-conditioned media, also caused a significant inhibition of lung NK activity. Furthermore, in vitro activation of AM with lipopolysaccharide (LPS, 5 micrograms/ml) and muramyl dipeptide (MDP, 20 micrograms/ml) significantly enhanced the inhibitory effect of AM on lung NK activity. Similarly, in vivo activation of AM locally by intratracheal instillation of attapulgite, an inflammatory agent, resulted in greater AM-mediated down regulation. Taken together, these data indicate that lung NK activity is modulated by locally derived factors and suggest that pharmacologic manipulation of AM may play a determining role in the activation of lung NK activity by biological response modifiers (BRM). |*Cytotoxicity, Immunologic[MESH] |*Magnesium Compounds[MESH] |*Silicon Compounds[MESH] |Animals[MESH] |Bronchoalveolar Lavage Fluid/cytology[MESH] |Killer Cells, Natural/*immunology[MESH] |Lipopolysaccharides/pharmacology[MESH] |Lung/cytology/*immunology[MESH] |Macrophage Activation/drug effects[MESH] |Macrophages/*immunology[MESH] |Magnesium/pharmacology[MESH] |Male[MESH] |Rats[MESH] |Rats, Inbred Strains[MESH]Modulation of lung-associated natural killer activity by resident and (epmc).pdf DeepDyve Pubget Overpricing