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10.1371/journal.pone.0055286 http://scihub22266oqcxt.onion/10.1371/journal.pone.0055286 23383138!3561381!23383138     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       PLoS+One 2013 ; 8 (1): e55286 Nephropedia Template TP {{tp|p=23383138|t=2013. Regulation of two renal chloride transporters, AE1 and pendrin, by electrolytes and aldosterone |pdf=|usr=}}{{23383138}} gab.com Text Regulation of two renal chloride transporters, AE1 and pendrin, by electrolytes and aldosterone JO: PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=23383138 #FOAvip The renal handling of salt and protons and bicarbonate are intricately linked through shared transport mechanisms for sodium, chloride, protons, and bicarbonate. In the collecting duct, the regulated fine-tuning of salt and acid-base homeostasis is achieved by a series of transport proteins located in different cell types, intercalated and principal cells. Intercalated cells are considered to be of less importance for salt handling but recent evidence has suggested that the anion exchanger pendrin may participate in salt reabsorption and blood pressure regulation. Here, we examined the regulated expression of two functionally related but differentially expressed anion exchangers, AE1 and pendrin, by dietary electrolyte intake and aldosterone. Cortical expression of pendrin was regulated on mRNA and protein level. The combination of NaHCO(3) and DOCA enhanced pendrin mRNA and protein levels, whereas DOCA or NaHCO(3) alone had no effect. NaCl or KHCO(3) increased pendrin mRNA, KCl decreased its mRNA abundance. On protein level, NH(4)Cl, NaCl, and KCl reduced pendrin expression, the other treatments were without effect. In contrast, AE1 mRNA or protein expression in kidney cortex was regulated by none of these treatments. In kidney medulla, NaHCO(3)/DOCA or NaHCO(3) alone enhanced AE1 mRNA levels. AE1 protein abundance was increased by NH(4)Cl, NaHCO(3)/DOCA, and NaCl. Immunolocalization showed that during NH(4)Cl treatment the relative number of AE1 positive cells was increased and pendrin expressing cells reduced. Thus, pendrin and AE1 are differentially regulated with distinct mechanisms that separately affect mRNA and protein levels. Pendrin is regulated by acidosis and chloride intake, whereas AE1 is enhanced by acidosis, NaCl, and the combination of DOCA and NaHCO(3). Twit Text FOAVip Regulation of two renal chloride transporters, AE1 and pendrin, by electrolytes and aldosterone ????PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=23383138 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=23383138 #FOAvip English Wikipedia <ref>{{Cite pmid|23383138}}</ref> Regulation of two renal chloride transporters, AE1 and pendrin, by electrolytes and aldosterone #MMPMID23383138 Mohebbi N; Perna A; van der Wijst J; Becker HM; Capasso G; Wagner CA PLoS One 2013[]; 8 (1): e55286 PMID23383138show ga The renal handling of salt and protons and bicarbonate are intricately linked through shared transport mechanisms for sodium, chloride, protons, and bicarbonate. In the collecting duct, the regulated fine-tuning of salt and acid-base homeostasis is achieved by a series of transport proteins located in different cell types, intercalated and principal cells. Intercalated cells are considered to be of less importance for salt handling but recent evidence has suggested that the anion exchanger pendrin may participate in salt reabsorption and blood pressure regulation. Here, we examined the regulated expression of two functionally related but differentially expressed anion exchangers, AE1 and pendrin, by dietary electrolyte intake and aldosterone. Cortical expression of pendrin was regulated on mRNA and protein level. The combination of NaHCO(3) and DOCA enhanced pendrin mRNA and protein levels, whereas DOCA or NaHCO(3) alone had no effect. NaCl or KHCO(3) increased pendrin mRNA, KCl decreased its mRNA abundance. On protein level, NH(4)Cl, NaCl, and KCl reduced pendrin expression, the other treatments were without effect. In contrast, AE1 mRNA or protein expression in kidney cortex was regulated by none of these treatments. In kidney medulla, NaHCO(3)/DOCA or NaHCO(3) alone enhanced AE1 mRNA levels. AE1 protein abundance was increased by NH(4)Cl, NaHCO(3)/DOCA, and NaCl. Immunolocalization showed that during NH(4)Cl treatment the relative number of AE1 positive cells was increased and pendrin expressing cells reduced. Thus, pendrin and AE1 are differentially regulated with distinct mechanisms that separately affect mRNA and protein levels. Pendrin is regulated by acidosis and chloride intake, whereas AE1 is enhanced by acidosis, NaCl, and the combination of DOCA and NaHCO(3). |Aldosterone/*metabolism[MESH] |Ammonium Chloride/pharmacology[MESH] |Analysis of Variance[MESH] |Animals[MESH] |Anion Exchange Protein 1, Erythrocyte/*metabolism[MESH] |Anion Transport Proteins/*metabolism[MESH] |Bicarbonates/pharmacology[MESH] |Blotting, Western[MESH] |Chromatography, Ion Exchange[MESH] |Desoxycorticosterone[MESH] |Electrolytes/*metabolism/urine[MESH] |Gene Expression Regulation/*drug effects[MESH] |Hydrogen-Ion Concentration[MESH] |Immunohistochemistry[MESH] |Kidney Tubules, Collecting/*metabolism[MESH] |Male[MESH] |Mice[MESH] |Mice, Inbred C57BL[MESH] |Potassium Compounds/pharmacology[MESH] |Real-Time Polymerase Chain Reaction[MESH] |Reverse Transcriptase Polymerase Chain Reaction[MESH] |Sodium Bicarbonate/pharmacology[MESH]Regulation of two renal chloride transporters, AE1 and pendrin, by ele(epmc).pdf DeepDyve Pubget Overpricing