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10.1111/cmi.12112 http://scihub22266oqcxt.onion/10.1111/cmi.12112 23351194!7162402!23351194     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Microbiol 2013 ; 15 (7): 1234-52 Nephropedia Template TP {{tp|p=23351194|t=2013. EWI-2wint promotes CD81 clustering that abrogates Hepatitis C Virus entry |pdf=|usr=}}{{23351194}} gab.com Text EWI-2wint promotes CD81 clustering that abrogates Hepatitis C Virus entry JO: Cell Microbiol http://www.kidney.de/pget.php?&tw=1&pmid=23351194 #FOAvip CD81 is a major receptor for Hepatitis C Virus (HCV). It belongs to the tetraspanin family whose members form dynamic clusters with numerous partner proteins and with one another, forming tetraspanin-enriched areas in the plasma membrane. In our study, we combined single-molecule microscopy and biochemistry experiments to investigate the clustering and membrane behaviour of CD81 in the context of cells expressing EWI-2wint, a natural inhibitor of HCV entry. Interestingly, we found that EWI-2wint reduces the global diffusion of CD81 molecules due to a decrease of the diffusion rate of mobile CD81 molecules and an increase in the proportion of confined molecules. Indeed, we demonstrated that EWI-2wint promotes CD81 clustering and confinement in CD81-enriched areas. In addition, we showed that EWI-2wint influences the colocalization of CD81 with Claudin-1 - a co-receptor required for HCV entry. Together, our results indicate that a change in membrane partitioning of CD81 occurs in the presence of EWI-2wint. This study gives new insights on the mechanism by which HCV enters into its target cells, namely by exploiting the dynamic properties of CD81. Twit Text FOAVip EWI-2wint promotes CD81 clustering that abrogates Hepatitis C Virus entry ????Cell Microbiol http://www.kidney.de/pget.php?&tw=1&pmid=23351194 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=23351194 #FOAvip English Wikipedia <ref>{{Cite pmid|23351194}}</ref> EWI-2wint promotes CD81 clustering that abrogates Hepatitis C Virus entry #MMPMID23351194 Potel J; Rassam P; Montpellier C; Kaestner L; Werkmeister E; Tews BA; Couturier C; Popescu CI; Baumert TF; Rubinstein E; Dubuisson J; Milhiet PE; Cocquerel L Cell Microbiol 2013[Jul]; 15 (7): 1234-52 PMID23351194show ga CD81 is a major receptor for Hepatitis C Virus (HCV). It belongs to the tetraspanin family whose members form dynamic clusters with numerous partner proteins and with one another, forming tetraspanin-enriched areas in the plasma membrane. In our study, we combined single-molecule microscopy and biochemistry experiments to investigate the clustering and membrane behaviour of CD81 in the context of cells expressing EWI-2wint, a natural inhibitor of HCV entry. Interestingly, we found that EWI-2wint reduces the global diffusion of CD81 molecules due to a decrease of the diffusion rate of mobile CD81 molecules and an increase in the proportion of confined molecules. Indeed, we demonstrated that EWI-2wint promotes CD81 clustering and confinement in CD81-enriched areas. In addition, we showed that EWI-2wint influences the colocalization of CD81 with Claudin-1 - a co-receptor required for HCV entry. Together, our results indicate that a change in membrane partitioning of CD81 occurs in the presence of EWI-2wint. This study gives new insights on the mechanism by which HCV enters into its target cells, namely by exploiting the dynamic properties of CD81. |*Host-Pathogen Interactions[MESH] |*Virus Internalization[MESH] |Antigens, CD/*metabolism[MESH] |Cell Line[MESH] |Hepacivirus/*physiology[MESH] |Hepatocytes/virology[MESH] |Humans[MESH] |Membrane Proteins/*metabolism[MESH] |Receptors, Virus/*metabolism[MESH]EWI-2wint promotes CD81 clustering that abrogates Hepatitis C Virus en(epmc).pdf DeepDyve Pubget Overpricing