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Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Front+Biosci+(Landmark+Ed) 2013 ; 18 (2): 696-715 Nephropedia Template TP
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Matrix proteins as centralized organizers of negative-sense RNA virions #MMPMID23276954
Liljeroos L; Butcher SJ
Front Biosci (Landmark Ed) 2013[Jan]; 18 (2): 696-715 PMID23276954show ga
Matrix proteins are essential components of most negative-sense RNA, enveloped viruses. They serve a wide range of duties ranging from self-driven membrane budding and coordination of other viral components to modulation of viral transcription. The functional similarity between these proteins is striking, despite major differences in their structures. Whereas biochemical and structural studies have partly been hindered by the inherent aggregation properties of these proteins, their cellular functions are beginning to be understood. In this review we summarize the current knowledge on negative-sense RNA virus matrix proteins and their interactions with other viral and cellular proteins. We also discuss the similarities and differences in matrix protein functions between the different families within the negative-sense RNA viruses.