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10.1111/imm.12036 http://scihub22266oqcxt.onion/10.1111/imm.12036 23216602!3575763!23216602     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=23216602&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       Immunology 2013 ; 138 (2): 105-15 Nephropedia Template TP {{tp|p=23216602|t=2013. The immunosuppressive tumour network: myeloid-derived suppressor cells, regulatory T cells and natural killer T cells |pdf=|usr=}}{{23216602}} gab.com Text The immunosuppressive tumour network: myeloid-derived suppressor cells, regulatory T cells and natural killer T cells JO: Immunology http://www.kidney.de/pget.php?&tw=1&pmid=23216602 #FOAvip Myeloid-derived suppressor cells (MDSC) and regulatory T (Treg) cells are major components of the immune suppressive tumour microenvironment (TME). Both cell types expand systematically in preclinical tumour models and promote T-cell dysfunction that in turn favours tumour progression. Clinical reports show a positive correlation between elevated levels of both suppressors and tumour burden. Recent studies further revealed that MDSCs can modulate the de novo development and induction of Treg cells. The overlapping target cell population of Treg cells and MDSCs is indicative for the importance and flexibility of immune suppression under pathological conditions. It also suggests the existence of common pathways that can be used for clinical interventions aiming to manipulate the TME. Elimination or reprogramming of the immune suppressive TME is one of the major current challenges in immunotherapy of cancer. Interestingly, recent findings suggest that natural killer T (NKT) cells can acquire the ability to convert immunosuppressive MDSCs into immunity-promoting antigen-presenting cells. Here we will review the cross-talk between MDSCs and other immune cells, focusing on Treg cells and NKT cells. We will consider its impact on basic and applied cancer research and discuss how targeting MDSCs may pave the way for future immunocombination therapies. Twit Text FOAVip The immunosuppressive tumour network: myeloid-derived suppressor cells, regulatory T cells and natural killer T cells ????Immunology http://www.kidney.de/pget.php?&tw=1&pmid=23216602 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=23216602 #FOAvip English Wikipedia <ref>{{Cite pmid|23216602}}</ref> The immunosuppressive tumour network: myeloid-derived suppressor cells, regulatory T cells and natural killer T cells #MMPMID23216602 Lindau D; Gielen P; Kroesen M; Wesseling P; Adema GJ Immunology 2013[Feb]; 138 (2): 105-15 PMID23216602show ga Myeloid-derived suppressor cells (MDSC) and regulatory T (Treg) cells are major components of the immune suppressive tumour microenvironment (TME). Both cell types expand systematically in preclinical tumour models and promote T-cell dysfunction that in turn favours tumour progression. Clinical reports show a positive correlation between elevated levels of both suppressors and tumour burden. Recent studies further revealed that MDSCs can modulate the de novo development and induction of Treg cells. The overlapping target cell population of Treg cells and MDSCs is indicative for the importance and flexibility of immune suppression under pathological conditions. It also suggests the existence of common pathways that can be used for clinical interventions aiming to manipulate the TME. Elimination or reprogramming of the immune suppressive TME is one of the major current challenges in immunotherapy of cancer. Interestingly, recent findings suggest that natural killer T (NKT) cells can acquire the ability to convert immunosuppressive MDSCs into immunity-promoting antigen-presenting cells. Here we will review the cross-talk between MDSCs and other immune cells, focusing on Treg cells and NKT cells. We will consider its impact on basic and applied cancer research and discuss how targeting MDSCs may pave the way for future immunocombination therapies. |*Immune Tolerance[MESH] |Animals[MESH] |Antigen-Presenting Cells/immunology/pathology[MESH] |Cell Communication/*immunology[MESH] |Humans[MESH] |Immunotherapy/methods[MESH] |Myeloid Cells/*immunology/pathology[MESH] |Natural Killer T-Cells/*immunology/pathology[MESH] |Neoplasms/*immunology/pathology/therapy[MESH]The immunosuppressive tumour network: myeloid-derived suppressor cells(epmc).pdf DeepDyve Pubget Overpricing