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A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1007/s00424-012-1190-z http://scihub22266oqcxt.onion/10.1007/s00424-012-1190-z 23207579!3562383!23207579     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=23207579&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       Pflugers+Arch 2013 ; 465 (2): 177-86 Nephropedia Template TP {{tp|p=23207579|t=2013. Novel insights into TRPV4 function in the kidney |pdf=|usr=}}{{23207579}} gab.com Text Novel insights into TRPV4 function in the kidney JO: Pflugers Arch http://www.kidney.de/pget.php?&tw=1&pmid=23207579 #FOAvip Kidneys are complex highly organized paired organs of nearly one million nephrons each. They rigorously process about 180 l of plasma daily to keep whole body homeostasis. To effectively perform such a titanic work, kidneys rely on mechanisms able to sense dynamic changes in composition and flow rates of protourine along the renal tubule. It is envisioned that Ca(2+)-permeable transient receptor potential (TRP) channels, and specifically mechanosensitive TRPV4, can serve to interpret these external mechanical cues in the form of elevated intracellular Ca(2+) concentration. This, in turn, initiates multiple cellular responses and adaptation mechanisms. The current review summarizes up-to-date knowledge about the sites of TRPV4 expression in renal tissue as well as discusses the functional role of the channel in cellular responses to hypotonicity and tubular flow. We will also provide insights as to how TRPV4 fits into classical polycystin mechanosensory complex in cilia and will speculate about previously underappreciated clinical implication of pharmacological TRPV4 targeting in treatment of polycystic kidney disease. Twit Text FOAVip Novel insights into TRPV4 function in the kidney ????Pflugers Arch http://www.kidney.de/pget.php?&tw=1&pmid=23207579 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=23207579 #FOAvip English Wikipedia <ref>{{Cite pmid|23207579}}</ref> Novel insights into TRPV4 function in the kidney #MMPMID23207579 Pochynyuk O; Zaika O; O'Neil RG; Mamenko M Pflugers Arch 2013[Feb]; 465 (2): 177-86 PMID23207579show ga Kidneys are complex highly organized paired organs of nearly one million nephrons each. They rigorously process about 180 l of plasma daily to keep whole body homeostasis. To effectively perform such a titanic work, kidneys rely on mechanisms able to sense dynamic changes in composition and flow rates of protourine along the renal tubule. It is envisioned that Ca(2+)-permeable transient receptor potential (TRP) channels, and specifically mechanosensitive TRPV4, can serve to interpret these external mechanical cues in the form of elevated intracellular Ca(2+) concentration. This, in turn, initiates multiple cellular responses and adaptation mechanisms. The current review summarizes up-to-date knowledge about the sites of TRPV4 expression in renal tissue as well as discusses the functional role of the channel in cellular responses to hypotonicity and tubular flow. We will also provide insights as to how TRPV4 fits into classical polycystin mechanosensory complex in cilia and will speculate about previously underappreciated clinical implication of pharmacological TRPV4 targeting in treatment of polycystic kidney disease. |Animals[MESH] |Calcium/metabolism[MESH] |Gene Expression[MESH] |Humans[MESH] |Kidney/*metabolism/physiology[MESH] |Polycystic Kidney Diseases/metabolism[MESH]Novel insights into TRPV4 function in the kidney (epmc).pdf DeepDyve Pubget Overpricing