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10.1002/biot.201200110

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23193100!7161785!23193100
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pmid23193100      Biotechnol+J 2013 ; 8 (1): 85-96
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  • Systems biology of pathogen-host interaction: networks of protein-protein interaction within pathogens and pathogen-human interactions in the post-genomic era #MMPMID23193100
  • Durmus Tekir SD; Ulgen KO
  • Biotechnol J 2013[Jan]; 8 (1): 85-96 PMID23193100show ga
  • Infectious diseases comprise some of the leading causes of death and disability worldwide. Interactions between pathogen and host proteins underlie the process of infection. Improved understanding of pathogen-host molecular interactions will increase our knowledge of the mechanisms involved in infection, and allow novel therapeutic solutions to be devised. Complete genome sequences for a number of pathogenic microorganisms, as well as the human host, has led to the revelation of their protein-protein interaction (PPI) networks. In this post-genomic era, pathogen-host interactions (PHIs) operating during infection can also be mapped. Detailed systematic analyses of PPI and PHI data together are required for a complete understanding of pathogenesis of infections. Here we review the striking results recently obtained during the construction and investigation of these networks. Emphasis is placed on studies producing large-scale interaction data by high-throughput experimental techniques.
  • |*Host-Pathogen Interactions[MESH]
  • |*Protein Interaction Maps[MESH]
  • |Communicable Diseases/*metabolism[MESH]
  • |Databases, Protein[MESH]
  • |Humans[MESH]


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