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10.1099/vir.0.047175-0 http://scihub22266oqcxt.onion/10.1099/vir.0.047175-0 23100370!ä!23100370 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Gen+Virol 2013 ; 94 (Pt 2): 263-269 Nephropedia Template TP {{tp|p=23100370|t=2013. The X proteins of bornaviruses interfere with type I interferon signalling |pdf=|usr=}}{{23100370}} gab.com Text The X proteins of bornaviruses interfere with type I interferon signalling JO: J Gen Virol http://www.kidney.de/pget.php?&tw=1&pmid=23100370 #FOAvip Borna disease virus (BDV) is a neurotropic, negative-stranded RNA virus causing persistent infection and progressive neurological disorders in a wide range of warm-blooded animals. The role of the small non-structural X protein in viral pathogenesis is not completely understood. Here we investigated whether the X protein of BDV and avian bornavirus (ABV) interferes with the type I interferon (IFN) system, similar to other non-structural proteins of negative-stranded RNA viruses. In luciferase reporter assays, we found that the X protein of various bornaviruses interfered with the type I IFN system at all checkpoints investigated, in contrast to previously reported findings, resulting in reduced type I IFN secretion. Twit Text FOAVip The X proteins of bornaviruses interfere with type I interferon signalling ????J Gen Virol http://www.kidney.de/pget.php?&tw=1&pmid=23100370 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=23100370 #FOAvip English Wikipedia <ref>{{Cite pmid|23100370}}</ref> The X proteins of bornaviruses interfere with type I interferon signalling #MMPMID23100370 Wensman JJ; Munir M; Thaduri S; Hornaeus K; Rizwan M; Blomstrom AL; Briese T; Lipkin WI; Berg M J Gen Virol 2013[Feb]; 94 (Pt 2): 263-269 PMID23100370show ga Borna disease virus (BDV) is a neurotropic, negative-stranded RNA virus causing persistent infection and progressive neurological disorders in a wide range of warm-blooded animals. The role of the small non-structural X protein in viral pathogenesis is not completely understood. Here we investigated whether the X protein of BDV and avian bornavirus (ABV) interferes with the type I interferon (IFN) system, similar to other non-structural proteins of negative-stranded RNA viruses. In luciferase reporter assays, we found that the X protein of various bornaviruses interfered with the type I IFN system at all checkpoints investigated, in contrast to previously reported findings, resulting in reduced type I IFN secretion. |*Immune Evasion[MESH] |Animals[MESH] |Bornaviridae/*immunology/*pathogenicity[MESH] |Cell Line[MESH] |Epithelial Cells/immunology/virology[MESH] |Genes, Reporter[MESH] |Humans[MESH] |Interferon Type I/*antagonists & inhibitors[MESH] |Luciferases/analysis/genetics[MESH] |Molecular Sequence Data[MESH] |RNA, Viral/genetics[MESH] |Sequence Analysis, DNA[MESH] |Viral Nonstructural Proteins/immunology/*metabolism[MESH]The X proteins of bornaviruses interfere with type I interferon signal(epmc).pdf DeepDyve Pubget Overpricing