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10.18632/aging.100488 http://scihub22266oqcxt.onion/10.18632/aging.100488 23075607/?report=reader!3492226!23075607     free     free     free Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Aging+(Albany+NY) 2012 ; 4 (9): 620-35 Nephropedia Template TP {{tp|p=23075607|t=2012. RhTFAM treatment stimulates mitochondrial oxidative metabolism and improves memory in aged mice |pdf=|usr=}}{{23075607}} gab.com Text RhTFAM treatment stimulates mitochondrial oxidative metabolism and improves memory in aged mice JO: Aging (Albany NY) http://www.kidney.de/pget.php?&tw=1&pmid=23075607 #FOAvip Mitochondrial function declines with age in postmitotic tissues such as brain, heart and skeletal muscle. Despite weekly exercise, aged mice showed substantial losses of mtDNA gene copy numbers and reductions in mtDNA gene transcription and mitobiogenesis signaling in brain and heart. We treated these mice with weekly intravenous injections of recombinant human mitochondrial transcription factor A (rhTFAM). RhTFAM treatment for one month increased mitochondrial respiration in brain, heart and muscle, POLMRT expression and mtDNA gene transcription in brain, and PGC-1 alpha mitobiogenesis signaling in heart. RhTFAM treatment reduced oxidative stress damage to brain proteins, improved memory in Morris water maze performance and increased brain protein levels of BDNF and synapsin. Microarray analysis showed co-expression of multiple Gene Ontology families in rhTFAM-treated aged brains compared to young brains. RhTFAM treatment reverses age-related memory impairments associated with loss of mitochondrial energy production in brain, increases levels of memory-related brain proteins and improves mitochondrial respiration in brain and peripheral tissues. Twit Text FOAVip RhTFAM treatment stimulates mitochondrial oxidative metabolism and improves memory in aged mice ????Aging (Albany NY) http://www.kidney.de/pget.php?&tw=1&pmid=23075607 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=23075607 #FOAvip English Wikipedia <ref>{{Cite pmid|23075607}}</ref> RhTFAM treatment stimulates mitochondrial oxidative metabolism and improves memory in aged mice #MMPMID23075607 Thomas RR; Khan SM; Smigrodzki RM; Onyango IG; Dennis J; Khan OM; Portelli FR; Bennett JP Jr Aging (Albany NY) 2012[Sep]; 4 (9): 620-35 PMID23075607show ga Mitochondrial function declines with age in postmitotic tissues such as brain, heart and skeletal muscle. Despite weekly exercise, aged mice showed substantial losses of mtDNA gene copy numbers and reductions in mtDNA gene transcription and mitobiogenesis signaling in brain and heart. We treated these mice with weekly intravenous injections of recombinant human mitochondrial transcription factor A (rhTFAM). RhTFAM treatment for one month increased mitochondrial respiration in brain, heart and muscle, POLMRT expression and mtDNA gene transcription in brain, and PGC-1 alpha mitobiogenesis signaling in heart. RhTFAM treatment reduced oxidative stress damage to brain proteins, improved memory in Morris water maze performance and increased brain protein levels of BDNF and synapsin. Microarray analysis showed co-expression of multiple Gene Ontology families in rhTFAM-treated aged brains compared to young brains. RhTFAM treatment reverses age-related memory impairments associated with loss of mitochondrial energy production in brain, increases levels of memory-related brain proteins and improves mitochondrial respiration in brain and peripheral tissues. |Aging[MESH] |Animals[MESH] |Blotting, Western[MESH] |Cell Respiration/drug effects[MESH] |DNA, Mitochondrial/drug effects[MESH] |DNA-Binding Proteins/*pharmacology[MESH] |Gene Expression/*drug effects[MESH] |Humans[MESH] |Maze Learning/drug effects[MESH] |Memory/*drug effects[MESH] |Mice[MESH] |Mitochondria/*drug effects[MESH] |Mitochondrial Proteins/*pharmacology[MESH] |Multiplex Polymerase Chain Reaction[MESH] |Oligonucleotide Array Sequence Analysis[MESH] |Oxidative Phosphorylation/drug effects[MESH] |Recombinant Proteins/pharmacology[MESH]RhTFAM treatment stimulates mitochondrial oxidative metabolism and imp(epmc).pdf DeepDyve Pubget Overpricing