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10.1152/physrev.00009.2012 http://scihub22266oqcxt.onion/10.1152/physrev.00009.2012 23073627!4519243!23073627     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Physiol+Rev 2012 ; 92 (4): 1577-617 Nephropedia Template TP {{tp|p=23073627|t=2012. Molecular physiology of SPAK and OSR1: two Ste20-related protein kinases regulating ion transport |pdf=|usr=}}{{23073627}} gab.com Text Molecular physiology of SPAK and OSR1: two Ste20-related protein kinases regulating ion transport JO: Physiol Rev http://www.kidney.de/pget.php?&tw=1&pmid=23073627 #FOAvip SPAK (Ste20-related proline alanine rich kinase) and OSR1 (oxidative stress responsive kinase) are members of the germinal center kinase VI subfamily of the mammalian Ste20 (Sterile20)-related protein kinase family. Although there are 30 enzymes in this protein kinase family, their conservation across the fungi, plant, and animal kingdom confirms their evolutionary importance. Already, a large volume of work has accumulated on the tissue distribution, binding partners, signaling cascades, and physiological roles of mammalian SPAK and OSR1 in multiple organ systems. After reviewing this basic information, we will examine newer studies that demonstrate the pathophysiological consequences to SPAK and/or OSR1 disruption, discuss the development and analysis of genetically engineered mouse models, and address the possible role these serine/threonine kinases might have in cancer proliferation and migration. Twit Text FOAVip Molecular physiology of SPAK and OSR1: two Ste20-related protein kinases regulating ion transport ????Physiol Rev http://www.kidney.de/pget.php?&tw=1&pmid=23073627 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=23073627 #FOAvip English Wikipedia <ref>{{Cite pmid|23073627}}</ref> Molecular physiology of SPAK and OSR1: two Ste20-related protein kinases regulating ion transport #MMPMID23073627 Gagnon KB; Delpire E Physiol Rev 2012[Oct]; 92 (4): 1577-617 PMID23073627show ga SPAK (Ste20-related proline alanine rich kinase) and OSR1 (oxidative stress responsive kinase) are members of the germinal center kinase VI subfamily of the mammalian Ste20 (Sterile20)-related protein kinase family. Although there are 30 enzymes in this protein kinase family, their conservation across the fungi, plant, and animal kingdom confirms their evolutionary importance. Already, a large volume of work has accumulated on the tissue distribution, binding partners, signaling cascades, and physiological roles of mammalian SPAK and OSR1 in multiple organ systems. After reviewing this basic information, we will examine newer studies that demonstrate the pathophysiological consequences to SPAK and/or OSR1 disruption, discuss the development and analysis of genetically engineered mouse models, and address the possible role these serine/threonine kinases might have in cancer proliferation and migration. |Animals[MESH] |Humans[MESH] |Ion Transport/*physiology[MESH] |Protein Serine-Threonine Kinases/genetics/*metabolism[MESH]Molecular physiology of SPAK and OSR1: two Ste20-related protein kinas(epmc).pdf DeepDyve Pubget Overpricing