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10.4149/av_2012_03_227

http://scihub22266oqcxt.onion/10.4149/av_2012_03_227
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23043602!ä!23043602

suck abstract from ncbi


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pmid23043602      Acta+Virol 2012 ; 56 (3): 227-33
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  • A mouse model of swine influenza virus H9N2 infection with acute lung injury #MMPMID23043602
  • Dong W; Li-Feng X; Cun-Lian W; Ming-Ju X; Rui-Hua Z; Ying L; Tong X
  • Acta Virol 2012[]; 56 (3): 227-33 PMID23043602show ga
  • BALB/c mice inoculated intranasally with A/swine/HeBei/012/2008/ (H9N2) virus (SIV), showing acute lung injury (ALI)/acute respiratory distress syndrome (ARDS), were observed for morbidity (lung histopathology, lung coefficient, lung wet/dry weight (W/D) ratio, arterial blood gas characteristics and inflammatory cells in bronchial alveolar lavage fluid (BALF)) and mortality. The results showed that, (1) on days 1-4 post infection (p.i.), mice appeared depressed and showed ruffled fur, reduced food intake, weight loss and hypoxemia with a decreased arterial partial oxygen pressure and an increased partial carbon dioxide pressure. (2) From day 4 p.i., mice began to die and showed pulmonary edema, hemorrhage and inflammatory cells in the alveolar exudate. The lung coefficient and lung W/D ratio significantly increased. (3) On days 3-8 p.i., inflammatory cells, especially alveolar macrophages and polymorphonuclears (PMNs) in BALF significantly increased. (4) The mortality rate reached 62.5%. This study established a successful animal model of ALI induced by infection with H9N2 SIV which may help in further investigations of the pathogenesis of human ALI/ARDS induced by H9N2 SIV infection. KEYWORDS: wine influenza virus; H9N2 subtype; acute lung injury; mouse.
  • |*Disease Models, Animal[MESH]
  • |*Mice[MESH]
  • |Acute Lung Injury/immunology/pathology/*virology[MESH]
  • |Animals[MESH]
  • |Cytokines/immunology[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Influenza A Virus, H9N2 Subtype/pathogenicity/*physiology[MESH]
  • |Influenza, Human/immunology/pathology/*virology[MESH]
  • |Lung/immunology/pathology/virology[MESH]


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