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10.1016/j.prostaglandins.2012.09.005 http://scihub22266oqcxt.onion/10.1016/j.prostaglandins.2012.09.005 23041292!ä!23041292 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Prostaglandins+Other+Lipid+Mediat 2012 ; 99 (3-4): 116-23 Nephropedia Template TP {{tp|p=23041292|t=2012. Activation of calcium-insensitive phospholipase A(2) (iPLA(2)) by P2X(7) receptors in murine peritoneal macrophages |pdf=|usr=}}{{23041292}} gab.com Text Activation of calcium-insensitive phospholipase A(2) (iPLA(2)) by P2X(7) receptors in murine peritoneal macrophages JO: Prostaglandins Other Lipid Mediat http://www.kidney.de/pget.php?&tw=1&pmid=23041292 #FOAvip Free fatty acid releases are triggered by PLA2 activation and are substrates for many enzymes such as cyclooxygenases. These reactions are responsible for the production of many prostaglandins implicated in the inflammation yet many purinergic receptors have been implicated in diseases characterised by chronic inflammation. The role of P2X receptors was evaluated in LPS-primed murine peritoneal macrophages which were labelled with either [(3)H]-oleic acid or [(3)H]-arachidonic acid. Ten mumolar thapsigargin and 1mM ATP stimulated the release of both unsaturated acids. ATP had no effect at 10 muM and ivermectin had no effect on the response to ATP. The response to ATP was inhibited by magnesium and was not observed with cells from P2X(7)(-/-) mice. The response to ATP was not affected by the removal of extracellular calcium and was inhibited by arachidonyltrifluoromethyl ketone and bromoenol lactone but not by pyrrophenone. The release of the [(3)H]-fatty acids by ATP and thapsigargin was diminished by PD-98058, an inhibitor of MEK-1. It was concluded that in LPS-primed macrophages, P2X(7) receptors, not P2X(4) receptors, activated an iPLA(2) and promoted the release of unsaturated fatty acids secondary to the activation of a kinase. This response might contribute to the inflammation provoked by extracellular ATP. Twit Text FOAVip Activation of calcium-insensitive phospholipase A(2) (iPLA(2)) by P2X(7) receptors in murine peritoneal macrophages ????Prostaglandins Other Lipid Mediat http://www.kidney.de/pget.php?&tw=1&pmid=23041292 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=23041292 #FOAvip English Wikipedia <ref>{{Cite pmid|23041292}}</ref> Activation of calcium-insensitive phospholipase A(2) (iPLA(2)) by P2X(7) receptors in murine peritoneal macrophages #MMPMID23041292 El Ouaaliti M; Seil M; Dehaye JP Prostaglandins Other Lipid Mediat 2012[Dec]; 99 (3-4): 116-23 PMID23041292show ga Free fatty acid releases are triggered by PLA2 activation and are substrates for many enzymes such as cyclooxygenases. These reactions are responsible for the production of many prostaglandins implicated in the inflammation yet many purinergic receptors have been implicated in diseases characterised by chronic inflammation. The role of P2X receptors was evaluated in LPS-primed murine peritoneal macrophages which were labelled with either [(3)H]-oleic acid or [(3)H]-arachidonic acid. Ten mumolar thapsigargin and 1mM ATP stimulated the release of both unsaturated acids. ATP had no effect at 10 muM and ivermectin had no effect on the response to ATP. The response to ATP was inhibited by magnesium and was not observed with cells from P2X(7)(-/-) mice. The response to ATP was not affected by the removal of extracellular calcium and was inhibited by arachidonyltrifluoromethyl ketone and bromoenol lactone but not by pyrrophenone. The release of the [(3)H]-fatty acids by ATP and thapsigargin was diminished by PD-98058, an inhibitor of MEK-1. It was concluded that in LPS-primed macrophages, P2X(7) receptors, not P2X(4) receptors, activated an iPLA(2) and promoted the release of unsaturated fatty acids secondary to the activation of a kinase. This response might contribute to the inflammation provoked by extracellular ATP. |Adenosine Triphosphate/metabolism/pharmacology[MESH] |Animals[MESH] |Arachidonic Acid/biosynthesis/metabolism[MESH] |Calcium/metabolism[MESH] |Enzyme Activation/drug effects[MESH] |Enzyme Inhibitors/pharmacology[MESH] |Gene Deletion[MESH] |Ivermectin/pharmacology[MESH] |Lipopolysaccharides/pharmacology[MESH] |MAP Kinase Kinase 1/antagonists & inhibitors/metabolism[MESH] |Macrophages, Peritoneal/cytology/*drug effects/enzymology[MESH] |Magnesium/metabolism/pharmacology[MESH] |Mice[MESH] |Mice, Knockout[MESH] |Oleic Acid/biosynthesis/metabolism[MESH] |Organic Chemicals/pharmacology[MESH] |Phospholipases A2, Calcium-Independent/*metabolism[MESH] |Purinergic P2 Receptor Agonists/*pharmacology[MESH] |Receptors, Purinergic P2X7/genetics/*metabolism[MESH] |Thapsigargin/pharmacology[MESH]Activation of calcium-insensitive phospholipase A(2) (iPLA(2)) by P2X((epmc).pdf DeepDyve Pubget Overpricing