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10.1016/j.semnephrol.2012.06.007 http://scihub22266oqcxt.onion/10.1016/j.semnephrol.2012.06.007 22958490!ä!22958490 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Semin+Nephrol 2012 ; 32 (4): 357-67 Nephropedia Template TP {{tp|p=22958490|t=2012. Parietal epithelial cells and podocytes in glomerular diseases |pdf=|usr=}}{{22958490}} gab.com Text Parietal epithelial cells and podocytes in glomerular diseases JO: Semin Nephrol http://www.kidney.de/pget.php?&tw=1&pmid=22958490 #FOAvip In recent years, it has become apparent that parietal epithelial cells (PECs) play an important role within the renal glomerulus, in particular in diseased conditions. In this review, we examine current knowledge about the role of PECs and their interactions with podocytes in development and under physiological conditions. A particular focus is on the crucial role of PECs and podocytes in two major glomerular disease entities. In rapidly progressive glomerulonephritis, PECs and podocytes proliferate and obstruct the tubular outlet, resulting in loss of the affected nephron. In focal and segmental glomerulosclerosis, PECs become activated and invade a segment of the glomerular tuft via an adhesion. From this entry site, activated PECs displace podocytes and deposit matrix. Thus, activated PECs are involved in inflammatory as well as degenerative glomerular diseases, which both can lead to irreversible loss of renal function. Twit Text FOAVip Parietal epithelial cells and podocytes in glomerular diseases ????Semin Nephrol http://www.kidney.de/pget.php?&tw=1&pmid=22958490 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=22958490 #FOAvip English Wikipedia <ref>{{Cite pmid|22958490}}</ref> Parietal epithelial cells and podocytes in glomerular diseases #MMPMID22958490 Smeets B; Moeller MJ Semin Nephrol 2012[Jul]; 32 (4): 357-67 PMID22958490show ga In recent years, it has become apparent that parietal epithelial cells (PECs) play an important role within the renal glomerulus, in particular in diseased conditions. In this review, we examine current knowledge about the role of PECs and their interactions with podocytes in development and under physiological conditions. A particular focus is on the crucial role of PECs and podocytes in two major glomerular disease entities. In rapidly progressive glomerulonephritis, PECs and podocytes proliferate and obstruct the tubular outlet, resulting in loss of the affected nephron. In focal and segmental glomerulosclerosis, PECs become activated and invade a segment of the glomerular tuft via an adhesion. From this entry site, activated PECs displace podocytes and deposit matrix. Thus, activated PECs are involved in inflammatory as well as degenerative glomerular diseases, which both can lead to irreversible loss of renal function. |Animals[MESH] |Epithelial Cells/cytology/metabolism/*pathology[MESH] |Glomerulonephritis/metabolism/pathology[MESH] |Glomerulosclerosis, Focal Segmental/*metabolism/*pathology[MESH] |Humans[MESH] |Kidney Glomerulus/pathology[MESH]Parietal epithelial cells and podocytes in glomerular diseases (epmc).pdf DeepDyve Pubget Overpricing