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10.1002/pmic.201200225 http://scihub22266oqcxt.onion/10.1002/pmic.201200225 22936401!7168038!22936401     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Proteomics 2012 ; 12 (21): 3193-205 Nephropedia Template TP {{tp|p=22936401|t=2012. Correlation between TGF-beta1 expression and proteomic profiling induced by severe acute respiratory syndrome coronavirus papain-like protease |pdf=|usr=}}{{22936401}} gab.com Text Correlation between TGF-beta1 expression and proteomic profiling induced by severe acute respiratory syndrome coronavirus papain-like protease JO: Proteomics http://www.kidney.de/pget.php?&tw=1&pmid=22936401 #FOAvip Severe acute respiratory syndrome (SARS) coronavirus (SARS-CoV) papain-like protease (PLpro), a deubiquitinating enzyme, demonstrates inactivation of interferon (IFN) regulatory factor 3 and NF-kappaB, reduction of IFN induction, and suppression of type I IFN signaling pathway. This study investigates cytokine expression and proteomic change induced by SARS-CoV PLpro in human promonocyte cells. PLpro significantly increased TGF-beta1 mRNA expression (greater than fourfold) and protein production (greater than threefold). Proteomic analysis, Western blot, and quantitative real-time PCR assays indicated PLpro upregulating TGF-beta1-associated genes: HSP27, protein disulfide isomerase A3 precursor, glial fibrillary acidic protein, vimentin, retinal dehydrogenase 2, and glutathione transferase omega-1. PLpro-activated ubiquitin proteasome pathway via upregulation of ubiquitin-conjugating enzyme E2-25k and proteasome subunit alpha type 5. Proteasome inhibitor MG-132 significantly reduced expression of TGF-beta1 and vimentin. PLpro upregulated HSP27, linking with activation of p38 MAPK and ERK1/2 signaling. Treatment with SB203580 and U0126 reduced PLpro-induced expression of TGF-beta1, vimentin, and type I collagen. Results point to SARS-CoV PLpro triggering TGF-beta1 production via ubiquitin proteasome, p38 MAPK, and ERK1/2-mediated signaling. Twit Text FOAVip Correlation between TGF-beta1 expression and proteomic profiling induced by severe acute respiratory syndrome coronavirus papain-like protease ????Proteomics http://www.kidney.de/pget.php?&tw=1&pmid=22936401 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=22936401 #FOAvip English Wikipedia <ref>{{Cite pmid|22936401}}</ref> Correlation between TGF-beta1 expression and proteomic profiling induced by severe acute respiratory syndrome coronavirus papain-like protease #MMPMID22936401 Li SW; Yang TC; Wan L; Lin YJ; Tsai FJ; Lai CC; Lin CW Proteomics 2012[Nov]; 12 (21): 3193-205 PMID22936401show ga Severe acute respiratory syndrome (SARS) coronavirus (SARS-CoV) papain-like protease (PLpro), a deubiquitinating enzyme, demonstrates inactivation of interferon (IFN) regulatory factor 3 and NF-kappaB, reduction of IFN induction, and suppression of type I IFN signaling pathway. This study investigates cytokine expression and proteomic change induced by SARS-CoV PLpro in human promonocyte cells. PLpro significantly increased TGF-beta1 mRNA expression (greater than fourfold) and protein production (greater than threefold). Proteomic analysis, Western blot, and quantitative real-time PCR assays indicated PLpro upregulating TGF-beta1-associated genes: HSP27, protein disulfide isomerase A3 precursor, glial fibrillary acidic protein, vimentin, retinal dehydrogenase 2, and glutathione transferase omega-1. PLpro-activated ubiquitin proteasome pathway via upregulation of ubiquitin-conjugating enzyme E2-25k and proteasome subunit alpha type 5. Proteasome inhibitor MG-132 significantly reduced expression of TGF-beta1 and vimentin. PLpro upregulated HSP27, linking with activation of p38 MAPK and ERK1/2 signaling. Treatment with SB203580 and U0126 reduced PLpro-induced expression of TGF-beta1, vimentin, and type I collagen. Results point to SARS-CoV PLpro triggering TGF-beta1 production via ubiquitin proteasome, p38 MAPK, and ERK1/2-mediated signaling. |Animals[MESH] |Cell Line[MESH] |Chi-Square Distribution[MESH] |Coronavirus 3C Proteases[MESH] |Cysteine Endopeptidases/*pharmacology[MESH] |Electrophoresis, Gel, Two-Dimensional[MESH] |Host-Pathogen Interactions[MESH] |Humans[MESH] |Leupeptins/pharmacology[MESH] |Mice[MESH] |Monocyte-Macrophage Precursor Cells/drug effects[MESH] |Proteasome Endopeptidase Complex/drug effects/metabolism[MESH] |Proteome/*drug effects[MESH] |Proteomics/methods[MESH] |RNA, Messenger/analysis/genetics[MESH] |Transforming Growth Factor beta1/*biosynthesis/genetics/metabolism[MESH] |Ubiquitin/metabolism[MESH] |Vimentin/metabolism[MESH]Correlation between TGF-beta1 expression and proteomic profiling induc(epmc).pdf DeepDyve Pubget Overpricing