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10.1038/nrd3802 http://scihub22266oqcxt.onion/10.1038/nrd3802 22935804!3518431!22935804     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Rev+Drug+Discov 2012 ; 11 (9): 709-30 Nephropedia Template TP {{tp|p=22935804|t=2012. Autophagy modulation as a potential therapeutic target for diverse diseases |pdf=|usr=}}{{22935804}} gab.com Text Autophagy modulation as a potential therapeutic target for diverse diseases JO: Nat Rev Drug Discov http://www.kidney.de/pget.php?&tw=1&pmid=22935804 #FOAvip Autophagy is an essential, conserved lysosomal degradation pathway that controls the quality of the cytoplasm by eliminating protein aggregates and damaged organelles. It begins when double-membraned autophagosomes engulf portions of the cytoplasm, which is followed by fusion of these vesicles with lysosomes and degradation of the autophagic contents. In addition to its vital homeostatic role, this degradation pathway is involved in various human disorders, including metabolic conditions, neurodegenerative diseases, cancers and infectious diseases. This article provides an overview of the mechanisms and regulation of autophagy, the role of this pathway in disease and strategies for therapeutic modulation. Twit Text FOAVip Autophagy modulation as a potential therapeutic target for diverse diseases ????Nat Rev Drug Discov http://www.kidney.de/pget.php?&tw=1&pmid=22935804 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=22935804 #FOAvip English Wikipedia <ref>{{Cite pmid|22935804}}</ref> Autophagy modulation as a potential therapeutic target for diverse diseases #MMPMID22935804 Rubinsztein DC; Codogno P; Levine B Nat Rev Drug Discov 2012[Sep]; 11 (9): 709-30 PMID22935804show ga Autophagy is an essential, conserved lysosomal degradation pathway that controls the quality of the cytoplasm by eliminating protein aggregates and damaged organelles. It begins when double-membraned autophagosomes engulf portions of the cytoplasm, which is followed by fusion of these vesicles with lysosomes and degradation of the autophagic contents. In addition to its vital homeostatic role, this degradation pathway is involved in various human disorders, including metabolic conditions, neurodegenerative diseases, cancers and infectious diseases. This article provides an overview of the mechanisms and regulation of autophagy, the role of this pathway in disease and strategies for therapeutic modulation. |Animals[MESH] |Autophagy/*drug effects/physiology[MESH] |Communicable Diseases/drug therapy/epidemiology[MESH] |Drug Delivery Systems/*methods/trends[MESH] |Humans[MESH] |Neurodegenerative Diseases/drug therapy/epidemiology[MESH] |Pharmaceutical Preparations/*administration & dosage[MESH]Autophagy modulation as a potential therapeutic target for diverse dis(epmc).pdf DeepDyve Pubget Overpricing