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10.1111/j.1399-3062.2012.00773.x

http://scihub22266oqcxt.onion/10.1111/j.1399-3062.2012.00773.x
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22931551!ä!22931551

suck abstract from ncbi


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pmid22931551      Transpl+Infect+Dis 2012 ; 14 (5): E64-70
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  • How many times can parvovirus B19-related anemia recur in solid organ transplant recipients? #MMPMID22931551
  • Gosset C; Viglietti D; Hue K; Antoine C; Glotz D; Pillebout E
  • Transpl Infect Dis 2012[Oct]; 14 (5): E64-70 PMID22931551show ga
  • Parvovirus B19 (PB19) infection is known to cause acute erythroblastopenia-mediated anemia in solid organ transplant (SOT) recipients. Intravenous immunoglobulins (IVIg) and the decrease of immunosuppression level are supposed to induce a long-term remission, although no consensus exists about the dose and the schedule of IVIg administrations. However, a few reports have shown that PB19-related anemia can recur despite this treatment, with a maximum of 3 recurrences reported. In this report, we describe in detail the cases of 2 kidney recipients with PB19 infection. They experienced, respectively, 9 and 7 PB19-related anemia recurrences. Immunosuppression level was decreased and IVIg were administered at each recurrence followed by a transitory normalization of hemoglobin level and a decrease of serum PB19 viral load. Episodes were separated by several months. These patients raise an original therapeutic management question about a frequent viral infection in SOT recipients. One patient is currently receiving IVIg every 3 months as a secondary prophylaxis without recurrence to date. These 2 case reports are followed by a review of the literature.
  • |Adult[MESH]
  • |Anemia/*etiology/prevention & control[MESH]
  • |Humans[MESH]
  • |Immunoglobulins, Intravenous/therapeutic use[MESH]
  • |Kidney Transplantation/*adverse effects[MESH]
  • |Male[MESH]
  • |Parvoviridae Infections/*complications/*virology[MESH]
  • |Parvovirus B19, Human/*isolation & purification[MESH]


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