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10.1371/journal.pone.0043206 http://scihub22266oqcxt.onion/10.1371/journal.pone.0043206 22912828!3418230!22912828     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       PLoS+One 2012 ; 7 (8): e43206 Nephropedia Template TP {{tp|p=22912828|t=2012. Global co-existence of two evolutionary lineages of parvovirus B19 1a, different in genome-wide synonymous positions |pdf=|usr=}}{{22912828}} gab.com Text Global co-existence of two evolutionary lineages of parvovirus B19 1a, different in genome-wide synonymous positions JO: PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=22912828 #FOAvip Parvovirus B19 (B19V) can cause infection in humans. To date, three genotypes of B19V, with subtypes, are known, of which genotype 1a is the most prevalent genotype in the Western world. We sequenced the genome of B19V strains of 65 asymptomatic, recently infected Dutch blood donors, to investigate the spatio-temporal distribution of B19V strains, in the years 2003-2009. The sequences were compared to B19V sequences from Dutch patients with fifth disease, and to global B19V sequences as available from GenBank. All Dutch B19V strains belonged to genotype 1a. Phylogenetic analysis of the strains from Dutch blood donors showed that two groups of genotype 1a co-exist. A clear-cut division into the two groups was also found among the B19V strains from Dutch patients, and among the B19V sequences in GenBank. The two groups of genotype 1a co-exist around the world and do not appear to differ in their ability to cause disease. Strikingly, the two groups of B19V predominantly differ in synonymous mutations, distributed throughout the entire genome of B19V. We propose to call the two groups of B19V genotype 1a respectively subtype 1a1 and 1a2. Twit Text FOAVip Global co-existence of two evolutionary lineages of parvovirus B19 1a, different in genome-wide synonymous positions ????PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=22912828 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=22912828 #FOAvip English Wikipedia <ref>{{Cite pmid|22912828}}</ref> Global co-existence of two evolutionary lineages of parvovirus B19 1a, different in genome-wide synonymous positions #MMPMID22912828 Molenaar-de Backer MW; Lukashov VV; van Binnendijk RS; Boot HJ; Zaaijer HL PLoS One 2012[]; 7 (8): e43206 PMID22912828show ga Parvovirus B19 (B19V) can cause infection in humans. To date, three genotypes of B19V, with subtypes, are known, of which genotype 1a is the most prevalent genotype in the Western world. We sequenced the genome of B19V strains of 65 asymptomatic, recently infected Dutch blood donors, to investigate the spatio-temporal distribution of B19V strains, in the years 2003-2009. The sequences were compared to B19V sequences from Dutch patients with fifth disease, and to global B19V sequences as available from GenBank. All Dutch B19V strains belonged to genotype 1a. Phylogenetic analysis of the strains from Dutch blood donors showed that two groups of genotype 1a co-exist. A clear-cut division into the two groups was also found among the B19V strains from Dutch patients, and among the B19V sequences in GenBank. The two groups of genotype 1a co-exist around the world and do not appear to differ in their ability to cause disease. Strikingly, the two groups of B19V predominantly differ in synonymous mutations, distributed throughout the entire genome of B19V. We propose to call the two groups of B19V genotype 1a respectively subtype 1a1 and 1a2. |*Biological Evolution[MESH] |*Phylogeny[MESH] |Base Sequence[MESH] |Cluster Analysis[MESH] |DNA Primers/genetics[MESH] |Demography[MESH] |Erythema Infectiosum/*virology[MESH] |Genome, Viral/*genetics[MESH] |Genotype[MESH] |Humans[MESH] |Likelihood Functions[MESH] |Models, Genetic[MESH] |Molecular Sequence Data[MESH] |Netherlands[MESH] |Parvovirus B19, Human/*genetics[MESH] |Sequence Analysis, DNA[MESH]Global co-existence of two evolutionary lineages of parvovirus B19 1a,(epmc).pdf DeepDyve Pubget Overpricing