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10.1111/j.1742-7843.2012.00929.x http://scihub22266oqcxt.onion/10.1111/j.1742-7843.2012.00929.x 22901271!ä!22901271 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Basic+Clin+Pharmacol+Toxicol 2013 ; 112 (2): 83-9 Nephropedia Template TP {{tp|p=22901271|t=2013. The role of waixenicin A as transient receptor potential melastatin 7 blocker |pdf=|usr=}}{{22901271}} gab.com Text The role of waixenicin A as transient receptor potential melastatin 7 blocker JO: Basic Clin Pharmacol Toxicol http://www.kidney.de/pget.php?&tw=1&pmid=22901271 #FOAvip Transient receptor potential melastatin 7 (TRPM7) plays a role in a number of physiological and pharmacological functions in variety of cells. The aim of this study was to clarify the role for TRPM7 channels and the effect of waixenicin A on the pacemaking activity of interstitial cells of Cajal (ICCs) and on the cell viability of the human gastric and breast adenocarcinoma cell lines, AGS and MCF-7, respectively. Waixenicin A decreased the amplitude of pacemaker potentials in cultured ICC clusters and inhibited TRPM7 currents, but had no effect on Ca(2+) -activated Cl(-) conductance (ANO1). Furthermore, waixenicin A was found to inhibit the growth and survival of AGS and MCF-7 cells. These findings indicate that TRPM7 channel modulates intestinal motility and regulates the pathophysiology of human gastric and breast adenocarcinoma cells. These findings suggest that TRPM7 channel be considered a potential target for the treatment of gut motor disorders and gastric and breast cancer. Twit Text FOAVip The role of waixenicin A as transient receptor potential melastatin 7 blocker ????Basic Clin Pharmacol Toxicol http://www.kidney.de/pget.php?&tw=1&pmid=22901271 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=22901271 #FOAvip English Wikipedia <ref>{{Cite pmid|22901271}}</ref> The role of waixenicin A as transient receptor potential melastatin 7 blocker #MMPMID22901271 Kim BJ; Nam JH; Kwon YK; So I; Kim SJ Basic Clin Pharmacol Toxicol 2013[Feb]; 112 (2): 83-9 PMID22901271show ga Transient receptor potential melastatin 7 (TRPM7) plays a role in a number of physiological and pharmacological functions in variety of cells. The aim of this study was to clarify the role for TRPM7 channels and the effect of waixenicin A on the pacemaking activity of interstitial cells of Cajal (ICCs) and on the cell viability of the human gastric and breast adenocarcinoma cell lines, AGS and MCF-7, respectively. Waixenicin A decreased the amplitude of pacemaker potentials in cultured ICC clusters and inhibited TRPM7 currents, but had no effect on Ca(2+) -activated Cl(-) conductance (ANO1). Furthermore, waixenicin A was found to inhibit the growth and survival of AGS and MCF-7 cells. These findings indicate that TRPM7 channel modulates intestinal motility and regulates the pathophysiology of human gastric and breast adenocarcinoma cells. These findings suggest that TRPM7 channel be considered a potential target for the treatment of gut motor disorders and gastric and breast cancer. |Acetates/*pharmacology[MESH] |Adenocarcinoma/drug therapy/pathology[MESH] |Animals[MESH] |Breast Neoplasms/drug therapy/pathology[MESH] |Cell Line, Tumor[MESH] |Cell Survival[MESH] |Diterpenes/*pharmacology[MESH] |Female[MESH] |Gastrointestinal Motility/drug effects[MESH] |Humans[MESH] |Interstitial Cells of Cajal/*drug effects/metabolism[MESH] |Male[MESH] |Membrane Potentials/drug effects[MESH] |Mice[MESH] |Mice, Inbred BALB C[MESH] |Protein Serine-Threonine Kinases[MESH] |Stomach Neoplasms/drug therapy/pathology[MESH]The role of waixenicin A as transient receptor potential melastatin 7 (epmc).pdf DeepDyve Pubget Overpricing