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10.1172/JCI57407 http://scihub22266oqcxt.onion/10.1172/JCI57407 22886306!3428075!22886306     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Clin+Invest 2012 ; 122 (9): 3355-67 Nephropedia Template TP {{tp|p=22886306|t=2012. PTH-independent regulation of blood calcium concentration by the calcium-sensing receptor |pdf=|usr=}}{{22886306}} gab.com Text PTH-independent regulation of blood calcium concentration by the calcium-sensing receptor JO: J Clin Invest http://www.kidney.de/pget.php?&tw=1&pmid=22886306 #FOAvip Tight regulation of calcium levels is required for many critical biological functions. The Ca2+-sensing receptor (CaSR) expressed by parathyroid cells controls blood calcium concentration by regulating parathyroid hormone (PTH) secretion. However, CaSR is also expressed in other organs, such as the kidney, but the importance of extraparathyroid CaSR in calcium metabolism remains unknown. Here, we investigated the role of extraparathyroid CaSR using thyroparathyroidectomized, PTH-supplemented rats. Chronic inhibition of CaSR selectively increased renal tubular calcium absorption and blood calcium concentration independent of PTH secretion change and without altering intestinal calcium absorption. CaSR inhibition increased blood calcium concentration in animals pretreated with a bisphosphonate, indicating that the increase did not result from release of bone calcium. Kidney CaSR was expressed primarily in the thick ascending limb of the loop of Henle (TAL). As measured by in vitro microperfusion of cortical TAL, CaSR inhibitors increased calcium reabsorption and paracellular pathway permeability but did not change NaCl reabsorption. We conclude that CaSR is a direct determinant of blood calcium concentration, independent of PTH, and modulates renal tubular calcium transport in the TAL via the permeability of the paracellular pathway. These findings suggest that CaSR inhibitors may provide a new specific treatment for disorders related to impaired PTH secretion, such as primary hypoparathyroidism. Twit Text FOAVip PTH-independent regulation of blood calcium concentration by the calcium-sensing receptor ????J Clin Invest http://www.kidney.de/pget.php?&tw=1&pmid=22886306 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=22886306 #FOAvip English Wikipedia <ref>{{Cite pmid|22886306}}</ref> PTH-independent regulation of blood calcium concentration by the calcium-sensing receptor #MMPMID22886306 Loupy A; Ramakrishnan SK; Wootla B; Chambrey R; de la Faille R; Bourgeois S; Bruneval P; Mandet C; Christensen EI; Faure H; Cheval L; Laghmani K; Collet C; Eladari D; Dodd RH; Ruat M; Houillier P J Clin Invest 2012[Sep]; 122 (9): 3355-67 PMID22886306show ga Tight regulation of calcium levels is required for many critical biological functions. The Ca2+-sensing receptor (CaSR) expressed by parathyroid cells controls blood calcium concentration by regulating parathyroid hormone (PTH) secretion. However, CaSR is also expressed in other organs, such as the kidney, but the importance of extraparathyroid CaSR in calcium metabolism remains unknown. Here, we investigated the role of extraparathyroid CaSR using thyroparathyroidectomized, PTH-supplemented rats. Chronic inhibition of CaSR selectively increased renal tubular calcium absorption and blood calcium concentration independent of PTH secretion change and without altering intestinal calcium absorption. CaSR inhibition increased blood calcium concentration in animals pretreated with a bisphosphonate, indicating that the increase did not result from release of bone calcium. Kidney CaSR was expressed primarily in the thick ascending limb of the loop of Henle (TAL). As measured by in vitro microperfusion of cortical TAL, CaSR inhibitors increased calcium reabsorption and paracellular pathway permeability but did not change NaCl reabsorption. We conclude that CaSR is a direct determinant of blood calcium concentration, independent of PTH, and modulates renal tubular calcium transport in the TAL via the permeability of the paracellular pathway. These findings suggest that CaSR inhibitors may provide a new specific treatment for disorders related to impaired PTH secretion, such as primary hypoparathyroidism. |Amino Acids/urine[MESH] |Animals[MESH] |Bone Density Conservation Agents/pharmacology/therapeutic use[MESH] |Calcium/*blood/metabolism/urine[MESH] |Creatinine/urine[MESH] |Diphosphonates/pharmacology/therapeutic use[MESH] |Hypoparathyroidism/blood/drug therapy[MESH] |Loop of Henle/metabolism[MESH] |Male[MESH] |Naphthalenes/pharmacology/therapeutic use[MESH] |Osteocalcin/blood[MESH] |Pamidronate[MESH] |Parathyroid Hormone/*metabolism[MESH] |Parathyroidectomy[MESH] |Permeability/drug effects[MESH] |Rats[MESH] |Rats, Sprague-Dawley[MESH] |Receptors, Calcium-Sensing/antagonists & inhibitors/metabolism/*physiology[MESH] |Sodium-Potassium-Chloride Symporters/metabolism[MESH] |Sodium-Potassium-Exchanging ATPase/metabolism[MESH]PTH-independent regulation of blood calcium concentration by the calci(epmc).pdf DeepDyve Pubget Overpricing