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10.1111/j.1369-1600.2012.00482.x http://scihub22266oqcxt.onion/10.1111/j.1369-1600.2012.00482.x 22862823/?report=reader!3504631!22862823     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Addict+Biol 2014 ; 19 (2): 312-5 Nephropedia Template TP {{tp|p=22862823|t=2014. Association of GATA4 sequence variation with alcohol dependence |pdf=|usr=}}{{22862823}} gab.com Text Association of GATA4 sequence variation with alcohol dependence JO: Addict Biol http://www.kidney.de/pget.php?&tw=1&pmid=22862823 #FOAvip To further explore reports of association of alcohol dependence and response to acamprosate treatment with the GATA4 rs13273672 single nucleotide polymorphism (SNP), we genotyped this and 10 other GATA4 SNPs in 816 alcohol-dependent cases and 1248 controls. We tested for association of alcohol dependence with the 11 SNPs individually and performed a global test for association using a principle components analysis. Our analyses demonstrate significant association between GATA4 and alcohol dependence at the gene level (P = 0.009) but no association with rs13273672. Further studies are needed to identify potential causal GATA4 variation(s) and the functional mechanism(s) contributing to this association. Twit Text FOAVip Association of GATA4 sequence variation with alcohol dependence ????Addict Biol http://www.kidney.de/pget.php?&tw=1&pmid=22862823 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=22862823 #FOAvip English Wikipedia <ref>{{Cite pmid|22862823}}</ref> Association of GATA4 sequence variation with alcohol dependence #MMPMID22862823 Karpyak VM; Winham SJ; Biernacka JM; Cunningham JM; Lewis KA; Geske JR; Colby CL; Abulseoud OA; Hall-Flavin DK; Loukianova LL; Schneekloth TD; Frye MA; Heit JA; Mrazek DA Addict Biol 2014[Mar]; 19 (2): 312-5 PMID22862823show ga To further explore reports of association of alcohol dependence and response to acamprosate treatment with the GATA4 rs13273672 single nucleotide polymorphism (SNP), we genotyped this and 10 other GATA4 SNPs in 816 alcohol-dependent cases and 1248 controls. We tested for association of alcohol dependence with the 11 SNPs individually and performed a global test for association using a principle components analysis. Our analyses demonstrate significant association between GATA4 and alcohol dependence at the gene level (P = 0.009) but no association with rs13273672. Further studies are needed to identify potential causal GATA4 variation(s) and the functional mechanism(s) contributing to this association. |Adult[MESH] |Aged[MESH] |Alcoholism/drug therapy/*genetics[MESH] |Female[MESH] |GATA4 Transcription Factor/*genetics[MESH] |Genetic Association Studies[MESH] |Humans[MESH] |Male[MESH] |Middle Aged[MESH] |Polymorphism, Single Nucleotide/*genetics[MESH]Association of GATA4 sequence variation with alcohol dependence (epmc).pdf DeepDyve Pubget Overpricing