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10.1186/1746-6148-8-114 http://scihub22266oqcxt.onion/10.1186/1746-6148-8-114 22809544/?report=reader!3439706!22809544     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=22809544&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       BMC+Vet+Res 2012 ; 8 (ä): 114 Nephropedia Template TP {{tp|p=22809544|t=2012. Orf virus interferes with MHC class I surface expression by targeting vesicular transport and Golgi |pdf=|usr=}}{{22809544}} gab.com Text Orf virus interferes with MHC class I surface expression by targeting vesicular transport and Golgi JO: BMC Vet Res http://www.kidney.de/pget.php?&tw=1&pmid=22809544 #FOAvip BACKGROUND: The Orf virus (ORFV), a zoonotic Parapoxvirus, causes pustular skin lesions in small ruminants (goat and sheep). Intriguingly, ORFV can repeatedly infect its host, despite the induction of a specific immunity. These immune modulating and immune evading properties are still unexplained. RESULTS: Here, we describe that ORFV infection of permissive cells impairs the intracellular transport of MHC class I molecules (MHC I) as a result of structural disruption and fragmentation of the Golgi apparatus. Depending on the duration of infection, we observed a pronounced co-localization of MHC I and COP-I vesicular structures as well as a reduction of MHC I surface expression of up to 50%. These subversion processes are associated with early ORFV gene expression and are accompanied by disturbed carbohydrate trimming of post-ER MHC I. The MHC I population remaining on the cell surface shows an extended half-life, an effect that might be partially controlled also by late ORFV genes. CONCLUSIONS: The presented data demonstrate that ORFV down-regulates MHC I surface expression in infected cells by targeting the late vesicular export machinery and the structure and function of the Golgi apparatus, which might aid to escape cellular immune recognition. Twit Text FOAVip Orf virus interferes with MHC class I surface expression by targeting vesicular transport and Golgi ????BMC Vet Res http://www.kidney.de/pget.php?&tw=1&pmid=22809544 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=22809544 #FOAvip English Wikipedia <ref>{{Cite pmid|22809544}}</ref> Orf virus interferes with MHC class I surface expression by targeting vesicular transport and Golgi #MMPMID22809544 Rohde J; Emschermann F; Knittler MR; Rziha HJ BMC Vet Res 2012[Jul]; 8 (ä): 114 PMID22809544show ga BACKGROUND: The Orf virus (ORFV), a zoonotic Parapoxvirus, causes pustular skin lesions in small ruminants (goat and sheep). Intriguingly, ORFV can repeatedly infect its host, despite the induction of a specific immunity. These immune modulating and immune evading properties are still unexplained. RESULTS: Here, we describe that ORFV infection of permissive cells impairs the intracellular transport of MHC class I molecules (MHC I) as a result of structural disruption and fragmentation of the Golgi apparatus. Depending on the duration of infection, we observed a pronounced co-localization of MHC I and COP-I vesicular structures as well as a reduction of MHC I surface expression of up to 50%. These subversion processes are associated with early ORFV gene expression and are accompanied by disturbed carbohydrate trimming of post-ER MHC I. The MHC I population remaining on the cell surface shows an extended half-life, an effect that might be partially controlled also by late ORFV genes. CONCLUSIONS: The presented data demonstrate that ORFV down-regulates MHC I surface expression in infected cells by targeting the late vesicular export machinery and the structure and function of the Golgi apparatus, which might aid to escape cellular immune recognition. |Animals[MESH] |Antibodies, Monoclonal[MESH] |Chlorocebus aethiops[MESH] |Ecthyma, Contagious/*virology[MESH] |Flow Cytometry[MESH] |Fluorescent Antibody Technique[MESH] |Gene Expression Regulation/*physiology[MESH] |Genes, MHC Class I/genetics/*physiology[MESH] |Golgi Apparatus/*physiology[MESH] |Orf virus/*physiology[MESH] |Protein Transport[MESH]Orf virus interferes with MHC class I surface expression by targeting (epmc).pdf DeepDyve Pubget Overpricing