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10.1021/cn100007x http://scihub22266oqcxt.onion/10.1021/cn100007x 22778836/?report=reader!3368653!22778836     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       ACS+Chem+Neurosci 2010 ; 1 (6): 420-34 Nephropedia Template TP {{tp|p=22778836|t=2010. Defining desirable central nervous system drug space through the alignment of molecular properties, in vitro ADME, and safety attributes |pdf=|usr=}}{{22778836}} gab.com Text Defining desirable central nervous system drug space through the alignment of molecular properties, in vitro ADME, and safety attributes JO: ACS Chem Neurosci http://www.kidney.de/pget.php?&tw=1&pmid=22778836 #FOAvip As part of our effort to increase survival of drug candidates and to move our medicinal chemistry design to higher probability space for success in the Neuroscience therapeutic area, we embarked on a detailed study of the property space for a collection of central nervous system (CNS) molecules. We carried out a thorough analysis of properties for 119 marketed CNS drugs and a set of 108 Pfizer CNS candidates. In particular, we focused on understanding the relationships between physicochemical properties, in vitro ADME (absorption, distribution, metabolism, and elimination) attributes, primary pharmacology binding efficiencies, and in vitro safety data for these two sets of compounds. This scholarship provides guidance for the design of CNS molecules in a property space with increased probability of success and may lead to the identification of druglike candidates with favorable safety profiles that can successfully test hypotheses in the clinic. Twit Text FOAVip Defining desirable central nervous system drug space through the alignment of molecular properties, in vitro ADME, and safety attributes ????ACS Chem Neurosci http://www.kidney.de/pget.php?&tw=1&pmid=22778836 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=22778836 #FOAvip English Wikipedia <ref>{{Cite pmid|22778836}}</ref> Defining desirable central nervous system drug space through the alignment of molecular properties, in vitro ADME, and safety attributes #MMPMID22778836 Wager TT; Chandrasekaran RY; Hou X; Troutman MD; Verhoest PR; Villalobos A; Will Y ACS Chem Neurosci 2010[Jun]; 1 (6): 420-34 PMID22778836show ga As part of our effort to increase survival of drug candidates and to move our medicinal chemistry design to higher probability space for success in the Neuroscience therapeutic area, we embarked on a detailed study of the property space for a collection of central nervous system (CNS) molecules. We carried out a thorough analysis of properties for 119 marketed CNS drugs and a set of 108 Pfizer CNS candidates. In particular, we focused on understanding the relationships between physicochemical properties, in vitro ADME (absorption, distribution, metabolism, and elimination) attributes, primary pharmacology binding efficiencies, and in vitro safety data for these two sets of compounds. This scholarship provides guidance for the design of CNS molecules in a property space with increased probability of success and may lead to the identification of druglike candidates with favorable safety profiles that can successfully test hypotheses in the clinic. |ATP Binding Cassette Transporter, Subfamily B, Member 1/metabolism[MESH] |Animals[MESH] |Cell Line[MESH] |Cell Survival/drug effects[MESH] |Central Nervous System Agents/*chemistry/metabolism/*pharmacology[MESH] |Central Nervous System/*drug effects[MESH] |Dogs[MESH] |Drug Design[MESH] |Epithelial Cells/drug effects[MESH] |Humans[MESH] |Safety[MESH]Defining desirable central nervous system drug space through the align(epmc).pdf DeepDyve Pubget Overpricing