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10.1371/journal.pone.0039457 http://scihub22266oqcxt.onion/10.1371/journal.pone.0039457 22745759!3382160!22745759     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       PLoS+One 2012 ; 7 (6): e39457 Nephropedia Template TP {{tp|p=22745759|t=2012. Effects of hyperuricemia on renal function of renal transplant recipients: a systematic review and meta-analysis of cohort studies |pdf=|usr=}}{{22745759}} gab.com Text Effects of hyperuricemia on renal function of renal transplant recipients: a systematic review and meta-analysis of cohort studies JO: PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=22745759 #FOAvip BACKGROUND: Hyperuricemia is an independent risk factor of nephropathy, but its role in renal transplant recipients (RTRs) is controversial. METHODS: Based on the methods of Cochrane systematic reviews, we searched MEDLINE (1948-2011.6), EMBASE (1956-2011.6), CBM (Chinese Biomedicine Database) (1978-2011.6) to identify cohort studies assessing the association between uric acid level and kidney allograft. Two authors independently screened the studies, assessed the risk of bias of included studies and extracted data. Unadjusted odds ratio (OR), mean difference (MD), adjusted hazard ratio (aHR) and their corresponding 95%CI were pooled to assess the effects of hyperuricemia on kidney allograft. RESULTS: Twelve cohort studies were included and the quality was moderate to high based on the NEWCASTLE-OTTAWA quality assessment scale. RTRs with hyperuricemia had lower eGFR (P<0.0001, 95%CI-16.34 approximately 6.14) and higher SCr (P<0.00001, 95%CI 0.17 approximately 0.31) than those with normal uric acid level. Meta-analysis showed that hyperuricemia was a risk factor of chronic allograft nephropathy (Unadjusted OR = 2.85, 95%CI 1.84 approximately 4.38, adjusted HR = 1.65, 95%CI 1.02 approximately 2.65) and graft loss (Unadjusted OR = 2.29, 95%CI 1.55 approximately 3.39; adjusted HR = 2.01, 95%CI 1.39 approximately 2.94). CONCLUSIONS: Current evidence suggests that hyperuricemia may be an independent risk factor of allograft dysfunction. Hyperuricemia may modestly increase the risk of poor outcomes of RTRs. Future research is needed to verify whether lowering uric acid level could improve the kidney function and prognosis of RTRs with hyperuricemia. Twit Text FOAVip Effects of hyperuricemia on renal function of renal transplant recipients: a systematic review and meta-analysis of cohort studies ????PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=22745759 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=22745759 #FOAvip English Wikipedia <ref>{{Cite pmid|22745759}}</ref> Effects of hyperuricemia on renal function of renal transplant recipients: a systematic review and meta-analysis of cohort studies #MMPMID22745759 Huang Y; Li YL; Huang H; Wang L; Yuan WM; Li J PLoS One 2012[]; 7 (6): e39457 PMID22745759show ga BACKGROUND: Hyperuricemia is an independent risk factor of nephropathy, but its role in renal transplant recipients (RTRs) is controversial. METHODS: Based on the methods of Cochrane systematic reviews, we searched MEDLINE (1948-2011.6), EMBASE (1956-2011.6), CBM (Chinese Biomedicine Database) (1978-2011.6) to identify cohort studies assessing the association between uric acid level and kidney allograft. Two authors independently screened the studies, assessed the risk of bias of included studies and extracted data. Unadjusted odds ratio (OR), mean difference (MD), adjusted hazard ratio (aHR) and their corresponding 95%CI were pooled to assess the effects of hyperuricemia on kidney allograft. RESULTS: Twelve cohort studies were included and the quality was moderate to high based on the NEWCASTLE-OTTAWA quality assessment scale. RTRs with hyperuricemia had lower eGFR (P<0.0001, 95%CI-16.34 approximately 6.14) and higher SCr (P<0.00001, 95%CI 0.17 approximately 0.31) than those with normal uric acid level. Meta-analysis showed that hyperuricemia was a risk factor of chronic allograft nephropathy (Unadjusted OR = 2.85, 95%CI 1.84 approximately 4.38, adjusted HR = 1.65, 95%CI 1.02 approximately 2.65) and graft loss (Unadjusted OR = 2.29, 95%CI 1.55 approximately 3.39; adjusted HR = 2.01, 95%CI 1.39 approximately 2.94). CONCLUSIONS: Current evidence suggests that hyperuricemia may be an independent risk factor of allograft dysfunction. Hyperuricemia may modestly increase the risk of poor outcomes of RTRs. Future research is needed to verify whether lowering uric acid level could improve the kidney function and prognosis of RTRs with hyperuricemia. |*Kidney Transplantation[MESH] |Cohort Studies[MESH] |Humans[MESH] |Hyperuricemia/*physiopathology[MESH]Effects of hyperuricemia on renal function of renal transplant recipie(epmc).pdf DeepDyve Pubget Overpricing