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10.1002/jnr.23091 http://scihub22266oqcxt.onion/10.1002/jnr.23091 22714899!ä!22714899 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Neurosci+Res 2012 ; 90 (10): 1932-40 Nephropedia Template TP {{tp|p=22714899|t=2012. Magnesium sulfate treatment decreases the initial brain damage alterations produced after perinatal asphyxia in fetal lambs |pdf=|usr=}}{{22714899}} gab.com Text Magnesium sulfate treatment decreases the initial brain damage alterations produced after perinatal asphyxia in fetal lambs JO: J Neurosci Res http://www.kidney.de/pget.php?&tw=1&pmid=22714899 #FOAvip The aim of this work was to analyze the effect of MgSO(4) treatment in the brain after hypoxic-ischemic (HI) injury in premature fetal lambs. Injury was induced by partial occlusion of umbilical cord for 60 min, and then the preterm lambs (80-90% of gestation) were randomly assigned to one of the following groups: control group, in which the animals were managed by conventional mechanical ventilation for 3 hr; 3 hr postpartial cord occlusion (3-hr-PCO) group, in which injured animals were managed by ventilation and then sacrificed 3 hr after HI; and MgSO(4) group, in which animals received 400 mg/kg MgSO(4) for 20 min soon after HI was induced and were managed by ventilation for 3 hr. Brains were analyzed for apoptosis by TUNEL assay. Cell viability and intracellular state studies were assessed by flow cytometry. The delayed death index was significantly increased in the 3-hr-PCO group in comparison with control. Administration of MgSO(4) elicited a delay in cell death that was similar to that in the control group. The 3-hr-PCO group showed a significantly higher concentration of reactive oxygen species, mitochondrial damage, and intracellular calcium in comparison with control and MgSO(4) - treated groups. Our results suggest that MgSO(4) treatment might have potential therapeutic benefits after the HI event. Twit Text FOAVip Magnesium sulfate treatment decreases the initial brain damage alterations produced after perinatal asphyxia in fetal lambs ????J Neurosci Res http://www.kidney.de/pget.php?&tw=1&pmid=22714899 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=22714899 #FOAvip English Wikipedia <ref>{{Cite pmid|22714899}}</ref> Magnesium sulfate treatment decreases the initial brain damage alterations produced after perinatal asphyxia in fetal lambs #MMPMID22714899 Goni-de-Cerio F; Alvarez A; Lara-Celador I; Alvarez FJ; Alonso-Alconada D; Hilario E J Neurosci Res 2012[Oct]; 90 (10): 1932-40 PMID22714899show ga The aim of this work was to analyze the effect of MgSO(4) treatment in the brain after hypoxic-ischemic (HI) injury in premature fetal lambs. Injury was induced by partial occlusion of umbilical cord for 60 min, and then the preterm lambs (80-90% of gestation) were randomly assigned to one of the following groups: control group, in which the animals were managed by conventional mechanical ventilation for 3 hr; 3 hr postpartial cord occlusion (3-hr-PCO) group, in which injured animals were managed by ventilation and then sacrificed 3 hr after HI; and MgSO(4) group, in which animals received 400 mg/kg MgSO(4) for 20 min soon after HI was induced and were managed by ventilation for 3 hr. Brains were analyzed for apoptosis by TUNEL assay. Cell viability and intracellular state studies were assessed by flow cytometry. The delayed death index was significantly increased in the 3-hr-PCO group in comparison with control. Administration of MgSO(4) elicited a delay in cell death that was similar to that in the control group. The 3-hr-PCO group showed a significantly higher concentration of reactive oxygen species, mitochondrial damage, and intracellular calcium in comparison with control and MgSO(4) - treated groups. Our results suggest that MgSO(4) treatment might have potential therapeutic benefits after the HI event. |Animals[MESH] |Animals, Newborn/*physiology[MESH] |Annexin A5/metabolism[MESH] |Apoptosis/drug effects[MESH] |Asphyxia/*pathology[MESH] |Brain Damage, Chronic/*pathology/*prevention & control[MESH] |Calcium/metabolism[MESH] |Carotid Arteries/pathology[MESH] |Cell Membrane/drug effects/ultrastructure[MESH] |Female[MESH] |Fetus/pathology[MESH] |Fluorescent Dyes[MESH] |Immunohistochemistry[MESH] |In Situ Nick-End Labeling[MESH] |Magnesium Sulfate/*pharmacology[MESH] |Membrane Potentials/drug effects[MESH] |Mitochondrial Membranes/drug effects[MESH] |Pregnancy[MESH] |Primed In Situ Labeling[MESH] |Reactive Oxygen Species/metabolism[MESH] |Rhodamine 123[MESH] |Sheep[MESH]Magnesium sulfate treatment decreases the initial brain damage alterat(epmc).pdf DeepDyve Pubget Overpricing